RPTOR and CILK1

Number of citations of the paper that reports this interaction (PubMedID 22356909)
50

Data Source:
BioGRID (enzymatic study, biochemical)

		RPTOR	CILK1
Description		regulatory associated protein of MTOR complex 1	ciliogenesis associated kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Membrane Dendrite TORC1 Complex Neuronal Cell Body Serine/threonine Protein Kinase Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Protein-containing Complex Binding 14-3-3 Protein Binding Enzyme-substrate Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation DNA Damage Response Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Negative Regulation Of Autophagy Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Social Behavior TORC1 Signaling Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Lipid Biosynthetic Process Protein Localization To Lysosome Regulation Of Biological Quality Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Odontoblast Differentiation Positive Regulation Of TORC1 Signaling Positive Regulation Of Pentose-phosphate Shunt	Protein Phosphorylation Signal Transduction Cell Projection Organization Intracellular Signal Transduction Intraciliary Anterograde Transport Intraciliary Retrograde Transport Intraciliary Transport Cilium Assembly
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs			Fostamatinib
Diseases			Endocrine-cerebro-osteodysplasia syndrome
GWAS		Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)
Interacting Genes		27 interacting genes: CILK1 DUXAP9 EIF4EBP1 EIF4EBP2 GTF3C5 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NLK NRBF2 OGT PLD2 PPDPF PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KA3 RPS6KB1 RRAGB WIPI2	6 interacting genes: APP BAG6 CDK20 FBXO7 RPTOR SMAD1
Entrez ID		57521	22858
HPRD ID		06184	09996
Ensembl ID		ENSG00000141564	ENSG00000112144
Uniprot IDs		Q8N122	A0A7I2PIU1 B3KQG4 Q9UPZ9
PDB IDs		5H64 6BCU 6BCX 6SB0 6SB2 6U62 7OWG 7PEA 7PEB 7PEC 7UX2 7UXC 7UXH 8ERA 8RCH 8RCK 8RCN 9F42 9F43 9F44 9F45
Enriched GO Terms of Interacting Partners?		TOR Signaling TORC1 Signaling Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Response To Nutrient Levels Intracellular Signal Transduction Regulation Of Translational Initiation Protein Serine Kinase Activity Insulin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Translation Negative Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Autophagosome Assembly Autophagosome Organization Negative Regulation Of Autophagy Cellular Response To Amino Acid Starvation Protein Kinase Activity Cellular Response To Starvation Negative Regulation Of Translation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Response To Starvation Post-transcriptional Regulation Of Gene Expression Kinase Activity Positive Regulation Of Small Molecule Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Vacuole Organization Regulation Of Glycolytic Process Organelle Assembly Positive Regulation Of Glycolytic Process Cytoplasmic Translation Positive Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of ATP Metabolic Process Nucleotide Binding Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Purine Nucleotide Metabolic Process	Positive Regulation Of Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Developmental Process Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Cycle Protein Kinase Binding Ubiquitin Protein Ligase Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of MiRNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Immune System Process Regulation Of Cell Differentiation Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Cellular Homeostasis Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Intracellular Chemical Homeostasis Regulation Of Multicellular Organismal Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Mesodermal Cell Fate Commitment
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