RPTOR and RRAGB

Number of citations of the paper that reports this interaction (PMID 24337580)
3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RPTOR	RRAGB
Gene Name		regulatory associated protein of MTOR, complex 1	Ras-related GTP binding B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Dendrite TORC1 Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus EGO Complex Intracellular Membrane-bounded Organelle Gtr1-Gtr2 GTPase Complex
	Molecular Function	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Binding Protein Kinase Binding Protein Complex Binding 14-3-3 Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Guanyl Ribonucleotide Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Insulin Receptor Signaling Pathway Regulation Of Cell Size Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase III Promoter Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat	Cellular Response To Starvation Regulation Of Autophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Cellular Response To Amino Acid Stimulus
Pathways		IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R HSF1-dependent transactivation Release of eIF4E Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Release of eIF4E Cellular response to heat stress S6K1-mediated signalling mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Obesity ( 23563607)
Protein-Protein Interactions		20 interactors: AKT1S1 EIF4EBP1 ICK IRS1 IRS2 MAPK1 MAPK3 MARK4 MLST8 MTOR PLD2 PRKAA1 PRKAA2 PRR5L RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB	5 interactors: APP MTOR RPTOR RRAGC RRAGD
Entrez ID		57521	10325
HPRD ID		06184	06710
Ensembl ID		ENSG00000141564	ENSG00000083750
Uniprot IDs		F5H7J5 Q6DKI0 Q8N122	Q5VZM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Peptide Hormone Enzyme Linked Receptor Protein Signaling Pathway Regulation Of TOR Signaling Response To Peptide Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cell Communication Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Response To Heat Response To Hormone Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Heat Fc-epsilon Receptor Signaling Pathway Response To Stimulus TOR Signaling Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Cellular Response To Heat Positive Regulation Of TOR Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Response To Amino Acid Positive Regulation Of TOR Signaling Cell Growth Cellular Response To Nutrient Levels Cellular Response To Extracellular Stimulus Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Response To Nutrient Levels Response To Extracellular Stimulus Cellular Response To Organonitrogen Compound Regulation Of Autophagy Growth Positive Regulation Of Transcription From RNA Polymerase III Promoter Response To External Stimulus Cellular Response To Acid Chemical Positive Regulation Of Intracellular Signal Transduction TOR Signaling Response To Organonitrogen Compound Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Cellular Response To Heat Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Endothelial Cell Proliferation Response To Stress Cellular Response To Heat Cellular Response To Stress Regulation Of Endothelial Cell Proliferation Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Carbohydrate Utilization Response To Heat Regulation Of Protein Kinase Activity Regulation Of Cell Size Cellular Response To Starvation Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Synaptic Growth At Neuromuscular Junction Response To Starvation Response To Organic Substance Collateral Sprouting In Absence Of Injury Response To Temperature Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Insulin Stimulus Regulation Of Protein Phosphorylation Cell Communication Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting
Tagcloud ?		ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Difference) ?		ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Intersection) ?