IRS1 and CSNK2B

Number of citations of the paper that reports this interaction (PMID 8349691)
15

Data Source:
HPRD (in vitro)

		IRS1	CSNK2B
Gene Name		insulin receptor substrate 1	casein kinase 2, beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Ciliary Basal Body Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PcG Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding	Protein Serine/threonine Kinase Activity Receptor Binding Protein Binding Transcription Factor Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Lipid Catabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Protein Kinase B Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Mitotic Cell Cycle Protein Phosphorylation Signal Transduction Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Wnt Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Protein Complex Assembly Regulation Of Protein Kinase Activity Regulation Of DNA Binding Endothelial Tube Morphogenesis
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs		[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Adiponectin levels ( 22479202) Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20686565) Triglycerides ( 20686565) Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ	175 interactors: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ADRBK1 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BCCIP BID BMI1 BRCA1 BTF3 C6orf136 C9orf114 CACNA1A CALM1 CBX4 CCDC115 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CENPB CHEK1 CHRNA4 CIC COIL COL4A2 COPS2 COPS3 COPS7A CPNE7 CPSF3L CSN1S1 CSN2 CSNK2A1 CSNK2A2 CTDP1 CTNNB1 DACT1 DALRD3 DENND5A DNMT1 EIF2S2 EIF5 EIF6 EPS8 ERCC8 ESR1 FAF1 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 GADD45GIP1 GAMT GBP2 GLB1 GNB5 HEXB HIRIP3 HNRNPA2B1 HOXB6 HTRA1 IER3IP1 IRS1 ITSN1 JUN KDM6B KIF2C LCK LEPR LMO4 LRP5L LYN LYST MAPK14 MBD4 MGEA5 MME MOXD1 MPP2 NAP1L1 NCF1 NMT2 NOLC1 NOTCH3 NRBP1 ODC1 PDS5A PFKFB4 PHC2 PHF11 PHRF1 PIN1 PITPNA PLXNA3 POT1 PPID PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PYROXD2 RFC1 RNF126 RNF7 RPA1 RPL13 RPL41 RPL5 RPS6KA2 RPS6KA5 RPS6KB1 RPS6KB2 RRAD RXRA SARNP SDHA SEC11A SHANK3 SHMT1 SHMT2 SIMC1 SIRT1 SNX2 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TCTEX1D2 TLE1 TNFAIP1 TOP2B TP53 TP53BP2 TSEN54 TUBB2B UBE2I UPF1 USO1 UTP14A VDAC1 VRK3 WDR1 WDR18 WFIKKN1 ZNF44 ZNF71 ZNF784 ZNHIT1
Entrez ID		3667	1460
HPRD ID		00943	00278
Ensembl ID		ENSG00000169047	ENSG00000204435
Uniprot IDs		P35568	N0E4C7 P67870 Q5SRQ6
PDB IDs		1IRS 1K3A 1QQG 2Z8C	1DS5 1JWH 1QF8 3EED 4DGL
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organic Substance Cellular Response To Organic Substance Response To Organonitrogen Compound Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Response To Peptide Hormone Cell Communication Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Stimulus Response To Hormone Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Innate Immune Response Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Immune System Process Immune Response Response To Stimulus Response To Insulin Defense Response Regulation Of Phosphorus Metabolic Process Response To Stress Immune System Process Fc Receptor Signaling Pathway Blood Coagulation Hemostasis Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Phosphorylation Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Response To Wounding Regulation Of Protein Phosphorylation	Cellular Metabolic Process Response To Growth Factor Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Developmental Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Cell Proliferation Anatomical Structure Development Metabolic Process Response To Organic Substance Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Cycle Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process System Development Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Cell Cycle Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Nitrogen Compound Metabolic Process Biosynthetic Process Cellular Protein Modification Process Cellular Response To Stimulus Cell Death Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Death Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Radiation Response To Radiation Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Light Stimulus Gene Expression Regulation Of Phosphorylation Peptidyl-amino Acid Modification Programmed Cell Death Cellular Aromatic Compound Metabolic Process
Tagcloud ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
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