IRS1 and TYK2

Number of citations of the paper that reports this interaction (PMID 8550573)
11

Data Source:
HPRD (in vivo)

		IRS1	TYK2
Gene Name		insulin receptor substrate 1	tyrosine kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Ciliary Basal Body Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Lipid Catabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Protein Kinase B Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Interferon alpha/beta signaling NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Interferon Signaling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation
Drugs		[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Adiponectin levels ( 22479202) Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20686565) Triglycerides ( 20686565) Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Psoriasis ( 20953190) Type 1 diabetes ( 19966805) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ	36 interactors: CBL COPS5 CRKL DNM2 EIF2AK2 FHL3 FYN GHR GNB2L1 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KRT40 LYN PDGFRB PIK3R1 PLAUR PRMT5 PTAFR PTPN1 PTPN6 PTPRC STAM2 STAT1 STAT2 TK1 TRAF4 VAV1 XRCC5
Entrez ID		3667	7297
HPRD ID		00943	01490
Ensembl ID		ENSG00000169047	ENSG00000105397
Uniprot IDs		P35568	P29597
PDB IDs		1IRS 1K3A 1QQG 2Z8C	3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organic Substance Cellular Response To Organic Substance Response To Organonitrogen Compound Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Response To Peptide Hormone Cell Communication Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Stimulus Response To Hormone Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Innate Immune Response Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Immune System Process Immune Response Response To Stimulus Response To Insulin Defense Response Regulation Of Phosphorus Metabolic Process Response To Stress Immune System Process Fc Receptor Signaling Pathway Blood Coagulation Hemostasis Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Phosphorylation Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Response To Wounding Regulation Of Protein Phosphorylation	JAK-STAT Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Organic Substance Regulation Of Immune Response Response To Growth Hormone Regulation Of Immune System Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Defense Response Regulation Of Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Immune Response Cell Surface Receptor Signaling Pathway Immune System Process Signal Transduction Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Kinase Activity Signaling Cell Communication Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Response To Cytokine Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Lymphocyte Activation Viral Process Fibroblast Growth Factor Receptor Signaling Pathway Response To Stimulus
Tagcloud ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin	3t3 carboxyl coimmunoprecipitated directed f442a functionally gh ghr heretofore hmw immunoblotting immunologically immunoprecipitation independently jak1 jak2 jak3 janus kd member mr physically preadipocytes referred signalling step terminus tyrosine whose
Tagcloud (Difference) ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist wortmannin	3t3 carboxyl coimmunoprecipitated directed f442a functionally ghr heretofore hmw immunoblotting immunologically immunoprecipitation independently jak1 jak2 jak3 janus kd member mr physically preadipocytes referred signalling step terminus whose
Tagcloud (Intersection) ?		gh tyrosine