IRS1 and CSNK2A1

Number of citations of the paper that reports this interaction (PMID 8349691)
15

Data Source:
HPRD (in vitro)

		IRS1	CSNK2A1
Gene Name		insulin receptor substrate 1	casein kinase 2, alpha 1 polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Ciliary Basal Body Intracellular Membrane-bounded Organelle	Nucleus Cytosol Plasma Membrane Sin3 Complex NuRD Complex PcG Protein Complex
	Molecular Function	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Hsp90 Protein Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Lipid Catabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Protein Kinase B Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Axon Guidance Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Growth Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Chaperone-mediated Protein Folding Mitotic Spindle Checkpoint
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs		[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID	(5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One Resveratrol 1,8-Di-Hydroxy-4-Nitro-Anthraquinone Benzamidine 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone Phosphoaminophosphonic Acid-Adenylate Ester Tetrabromo-2-Benzotriazole DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one N,N\'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole 1,2,5,8-tetrahydroxyanthracene-9,10-dione Ellagic Acid
Diseases
GWAS		Adiponectin levels ( 22479202) Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20686565) Triglycerides ( 20686565) Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ	366 interactors: ABCA1 ACACA ACAT2 ACE ACIN1 AIP AKAP8 AKT1 ALKBH5 ANP32B APC APEX1 APOE APP AQP4 ARL6IP4 ARMCX3 ARNT ARR3 ARRB2 ASIC3 ATF1 ATF2 ATP2B1 ATP5A1 BCLAF1 BDP1 BID BIRC6 BMS1 BRCA1 BRF1 C1orf109 C1R CALM1 CALU CANX CARD9 CASP2 CASQ2 CAV1 CAV2 CCDC6 CD2BP2 CD5 CDC25B CDC37 CDH1 CDK1 CDKN1A CFDP1 CHD4 CHUK CIRBP CLASP2 CLNS1A CLTB COPS2 COPS3 COPS7A CPSF6 CPSF7 CREBBP CREM CSN1S1 CSN2 CSNK2B CTDP1 CTNNB1 CUX2 CXCL8 DDIT3 DDX17 DDX21 DDX24 DDX3X DDX54 DEK DHX16 DHX38 DKC1 DTD1 DVL1 DVL3 EEF1B2 EEF1D EGR1 EIF2B5 EIF2S1 EIF2S2 EIF3J EIF4B EIF4EBP1 EIF5 EIF5B ERH EXOSC9 F11R F5 FAF1 FCP1 FGF1 FGF2 FIBP FIP1L1 FKBP3 FKBP4 FLG FNBP4 FOS FTSJ3 FXR1 GABRR1 GABRR2 GAP43 GGA1 GMFB GMNN GPI GPN1 GTF2A1 GTF2A1L GTF2F1 GYS1 HCLS1 HDAC1 HDAC2 HDAC3 HDGFRP2 HDLBP HES6 HIF1A HIRIP3 HMGA1 HMGA2 HMOX2 HNRNPA2B1 HNRNPC HNRNPDL HNRNPL HOXB7 HSF1 HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPB8 HSPH1 HTATSF1 IFI16 IFRD1 IGF2R IGFBP3 IL16 INF2 IRF2 IRS1 ITCH IWS1 JUN KANK2 KIF1C KIF5C KLF1 KPNA4 L1CAM LARP1 LARP7 LEO1 LGALS3 LIG1 LRRC59 LSM14A LTV1 MAF1 MAGEA11 MAK16 MAPK14 MAPT MAX MAZ MCM2 MCM3 MDC1 MEF2C MFAP1 MGMT MME MPHOSPH10 MRPL38 MRPL4 MS4A1 MSH6 MTDH MYB MYC MYCN MYF5 MYH9 NAF1 NAP1L4 NCAPD2 NCL NCOR1 NFKBIA NFKBIB NFYA NKX2-5 NMD3 NMT1 NOL3 NOLC1 NOP56 NOP58 NPM1 NRF1 NUP98 NXF1 OGT OSBP PACS1 PAFAH1B1 PAK1 PDAP1 PDCD4 PDIA6 PGR PIAS1 PIN1 PIN4 PLEKHO1 PML PNN POLR2A PPAN PPBP PPP1R1B PPP1R2 PPP1R8 PPP2R4 PRCC PRKACB PRNP PRPF38A PRPF40A PSEN2 PSIP1 PSMA3 PSMA4 PTEN PTPN1 PTPRC PURB RANGAP1 RBM10 RBM17 RBM33 RBMX RELA RGS19 RIOK2 RNF111 RNF7 RPL13 RPL5 RPL6 RPLP0 RPLP1 RPRD2 RPS18 RPS3 RPS6KB1 RRAD RRP12 RRP1B RRP9 RSF1 RSL1D1 SAFB SAP30BP SAT1 SCNN1A SEPT2 SERBP1 SERPINF1 SF3A1 SF3B1 SF3B2 SFPQ SHOX SLC18A2 SLC4A1AP SLIRP SMARCC2 SNCA SND1 SNRNP70 SP1 SPATS2L SPI1 SPIB SPP1 SPTBN1 SQSTM1 SREK1 SRF SRRM1 SRRM2 SRRT SRSF10 SRSF11 SRSF2 SSB SSRP1 STAC3 STMN1 STX1A SUB1 SUDS3 SUGT1 SUPT5H SUPT6H SURF6 TCF7L2 TH THAP1 THOC5 THRAP3 TMOD3 TMPO TNKS1BP1 TNP1 TOP1 TOP2A TP53 TSPY1 UBAC1 UBE2R2 UBTF USP24 UTP14A UTP18 VAMP4 VDR VHL VTN WAS WDR44 WDR55 WEE1 XK XKRY XRCC1 XRCC4 XRCC5 XRCC6 XRN2 YBX1 YWHAB YWHAQ ZC3H13 ZC3H15 ZC3H8 ZFC3H1 ZHX1 ZRANB2
Entrez ID		3667	1457
HPRD ID		00943	00277
Ensembl ID		ENSG00000169047
Uniprot IDs		P35568	P68400
PDB IDs		1IRS 1K3A 1QQG 2Z8C	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 4DGL 4FBX 4GRB 4GYW 4GYY 4GZ3 4IB5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organic Substance Cellular Response To Organic Substance Response To Organonitrogen Compound Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Response To Peptide Hormone Cell Communication Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Stimulus Response To Hormone Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Innate Immune Response Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Immune System Process Immune Response Response To Stimulus Response To Insulin Defense Response Regulation Of Phosphorus Metabolic Process Response To Stress Immune System Process Fc Receptor Signaling Pathway Blood Coagulation Hemostasis Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Phosphorylation Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Response To Wounding Regulation Of Protein Phosphorylation	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Processing Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process MRNA Processing Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Cellular Process Regulation Of RNA Metabolic Process Response To Stress RNA Splicing Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Developmental Process Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To Organic Substance Programmed Cell Death Death Viral Process Cell Death Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process
Tagcloud ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?