IRS1 and PLCG2

  • Number of citations of the paper that reports this interaction (PMID 22974441)
  • 2
  • Data Source:
  • BioGRID (unspecified method)

IRS1

PLCG2

Gene Name insulin receptor substrate 1 phospholipase C, gamma 2 (phosphatidylinositol-specific)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ 34 interactors: BLK BLNK BTK CBLB CD19 DAPP1 EGFR EPOR ERBB2 FCER1G FLT1 FYN GAB1 GAB2 HCK IRS1 ITK JAK1 JAK2 KDR KHDRBS1 LAT LAT2 LCK LCP2 LIME1 LYN NPM1 PRKD1 SH3BP2 SHC1 SYK TEC ZNF512B
Entrez ID 3667 5336
HPRD ID 00943 02570
Ensembl ID ENSG00000169047 ENSG00000197943
Uniprot IDs P35568 P16885
PDB IDs 1IRS 1K3A 1QQG 2Z8C 2K2J 2W2W 2W2X
Enriched GO Terms of Interacting Partners?
Tagcloud ?
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
16x10  associations  chrne  comprehensively  dysregulated  escc  esccs  esophageal  fyn  gc  gcs  germline  gnai3  han  itch  map2k1  map2k4  mapk8  observe  pak4  pik3r3  prlr  rank  resampling  rps6kb2  tln1  validate  warranted  wasl 
Tagcloud (Difference) ?
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
16x10  associations  chrne  comprehensively  dysregulated  escc  esccs  esophageal  fyn  gc  gcs  germline  gnai3  han  itch  map2k1  map2k4  mapk8  observe  pak4  pik3r3  prlr  rank  resampling  rps6kb2  tln1  validate  warranted  wasl 
Tagcloud (Intersection) ?