RPTOR and RPS6KB1

Number of citations of the paper that reports this interaction (PubMedID 16183647)
0

Data Source:
HPRD (in vitro)

		RPTOR	RPS6KB1
Description		regulatory associated protein of MTOR complex 1	ribosomal protein S6 kinase B1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Membrane Dendrite TORC1 Complex Neuronal Cell Body Serine/threonine Protein Kinase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Neuron Projection Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Protein-containing Complex Binding 14-3-3 Protein Binding Enzyme-substrate Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation DNA Damage Response Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Negative Regulation Of Autophagy Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Social Behavior TORC1 Signaling Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Lipid Biosynthetic Process Protein Localization To Lysosome Regulation Of Biological Quality Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Odontoblast Differentiation Positive Regulation Of TORC1 Signaling Positive Regulation Of Pentose-phosphate Shunt	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response Cytoplasmic Translation Regulation Of Translation Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Signal Transduction Germ Cell Development Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Peptidyl-serine Phosphorylation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Cellular Response To Nutrient Levels Cellular Response To Nutrient TOR Signaling Cellular Response To Insulin Stimulus TORC1 Signaling TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Long-chain Fatty Acid Import Into Cell Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Type II Interferon Cellular Response To Growth Factor Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of TORC2 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	mTORC1-mediated signalling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)	A body shape index ( 34021172) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)
Interacting Genes		27 interacting genes: CILK1 DUXAP9 EIF4EBP1 EIF4EBP2 GTF3C5 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NLK NRBF2 OGT PLD2 PPDPF PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KA3 RPS6KB1 RRAGB WIPI2	61 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 UBC URI1 USP11 XPO1
Entrez ID		57521	6198
HPRD ID		06184	10202
Ensembl ID		ENSG00000141564	ENSG00000108443
Uniprot IDs		Q8N122	P23443
PDB IDs		5H64 6BCU 6BCX 6SB0 6SB2 6U62 7OWG 7PEA 7PEB 7PEC 7UX2 7UXC 7UXH 8ERA 8RCH 8RCK 8RCN 9F42 9F43 9F44 9F45	3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK 7N91 7N93
Enriched GO Terms of Interacting Partners?		TOR Signaling TORC1 Signaling Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Response To Nutrient Levels Intracellular Signal Transduction Regulation Of Translational Initiation Protein Serine Kinase Activity Insulin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Translation Negative Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Autophagosome Assembly Autophagosome Organization Negative Regulation Of Autophagy Cellular Response To Amino Acid Starvation Protein Kinase Activity Cellular Response To Starvation Negative Regulation Of Translation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Response To Starvation Post-transcriptional Regulation Of Gene Expression Kinase Activity Positive Regulation Of Small Molecule Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Vacuole Organization Regulation Of Glycolytic Process Organelle Assembly Positive Regulation Of Glycolytic Process Cytoplasmic Translation Positive Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of ATP Metabolic Process Nucleotide Binding Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Purine Nucleotide Metabolic Process	Intracellular Signal Transduction TOR Signaling Regulation Of Protein Metabolic Process Regulation Of Autophagy Cytosol Kinase Activity TORC1 Signaling Protein Kinase Activity Regulation Of TORC1 Signaling Positive Regulation Of Catabolic Process Protein Phosphorylation Regulation Of TOR Signaling Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Metabolic Process Regulation Of Macroautophagy Regulation Of Signal Transduction Cellular Response To Nutrient Levels Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of TOR Signaling Peptidyl-threonine Phosphorylation Cytoplasm Transferase Activity Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Autophagy Regulation Of Translational Initiation Cellular Response To Stress Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Modification Process Protein Serine Kinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Cell Projection Organization Positive Regulation Of Autophagy Response To Stress Negative Regulation Of TOR Signaling
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