BAAT and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		BAAT	MLH3
Description		bile acid-CoA:amino acid N-acyltransferase	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Protein Binding N-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Thiolester Hydrolase Activity Choloyl-CoA Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Glycine N-choloyltransferase Activity Carboxylic Ester Hydrolase Activity Medium-chain Fatty Acyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Liver Development Bile Acid Conjugation Glycine Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Bile Acid Metabolic Process Taurine Metabolic Process Animal Organ Regeneration Monocarboxylic Acid Metabolic Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Peroxisomal protein import Peroxisomal protein import	Meiotic recombination
Drugs		Glycine
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia	Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS			Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: APC AURKA BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 GOLGA8DP GOLGA8EP GOLGA8F MCC MLH1 MLH3 MUTYH ODC1 PDGFRL PEX5 PTPRJ RAD54B RB1 SLC7A11 SMAD4 SRC	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		570	27030
HPRD ID		08376	05094
Ensembl ID		ENSG00000136881	ENSG00000119684
Uniprot IDs		Q14032	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Ruffle Membrane Regulation Of Protein Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Gamma-catenin Binding Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Chiasma Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Cell Population Proliferation Reciprocal Meiotic Recombination Mismatch Repair Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Phosphorylation Response To Stress Regulation Of Protein Modification Process Regulation Of Mitotic Nuclear Division Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Programmed Cell Death Homologous Recombination Mismatch Repair Complex Cellular Response To Stress Negative Regulation Of Immature T Cell Proliferation Regulation Of Cell-matrix Adhesion Regulation Of Cellular Component Organization MutSalpha Complex Binding Regulation Of Nuclear Division Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Growth Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell-substrate Adhesion Regulation Of Catalytic Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Mismatched DNA Binding	Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration
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