BAAT and MCC

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		BAAT	MCC
Description		bile acid-CoA:amino acid N-acyltransferase	MCC regulator of Wnt signaling pathway
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Binding N-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Thiolester Hydrolase Activity Choloyl-CoA Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Glycine N-choloyltransferase Activity Carboxylic Ester Hydrolase Activity Medium-chain Fatty Acyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Liver Development Bile Acid Conjugation Glycine Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Bile Acid Metabolic Process Taurine Metabolic Process Animal Organ Regeneration Monocarboxylic Acid Metabolic Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Peroxisomal protein import Peroxisomal protein import
Drugs		Glycine
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS			Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		24 interacting genes: APC AURKA BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 GOLGA8DP GOLGA8EP GOLGA8F MCC MLH1 MLH3 MUTYH ODC1 PDGFRL PEX5 PTPRJ RAD54B RB1 SLC7A11 SMAD4 SRC	77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		570	4163
HPRD ID		08376	01157
Ensembl ID		ENSG00000136881	ENSG00000171444
Uniprot IDs		Q14032	P23508
PDB IDs			6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Ruffle Membrane Regulation Of Protein Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Gamma-catenin Binding Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Chiasma Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Cell Population Proliferation Reciprocal Meiotic Recombination Mismatch Repair Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Phosphorylation Response To Stress Regulation Of Protein Modification Process Regulation Of Mitotic Nuclear Division Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Programmed Cell Death Homologous Recombination Mismatch Repair Complex Cellular Response To Stress Negative Regulation Of Immature T Cell Proliferation Regulation Of Cell-matrix Adhesion Regulation Of Cellular Component Organization MutSalpha Complex Binding Regulation Of Nuclear Division Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Growth Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell-substrate Adhesion Regulation Of Catalytic Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Mismatched DNA Binding	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome
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