GRIPAP1 and DISC1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		GRIPAP1	DISC1
Description		GRIP1 associated protein 1	DISC1 scaffold protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Membrane Axon Dendrite Early Endosome Membrane Presynaptic Membrane Cell Projection Neuronal Cell Body Synapse Recycling Endosome Membrane Blood Microparticle Glutamatergic Synapse Extrinsic Component Of Postsynaptic Early Endosome Membrane	Cytoplasm Mitochondrion Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Axon Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding	Protein Binding Kinesin Binding Identical Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Protein Transport Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Negative Regulation Of Protein Localization Negative Regulation Of Receptor Clustering	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Ubiquitin-dependent Protein Catabolic Process Nervous System Development Intracellular Protein Localization Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Pyramidal Neuron Migration To Cerebral Cortex Positive Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Axon Extension Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Neuron Cellular Homeostasis Protein Localization To Centrosome Regulation Of Synapse Maturation Regulation Of Postsynapse Organization Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494)	Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Bell's palsy ( 33602968) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)
Interacting Genes		70 interacting genes: AARD ANKRD11 ARL15 ATG5 BYSL CASP3 CBX8 CCDC185 CCDC187 CCNH CCNT1 CDC37 CEP57L1 CFAP53 CWF19L2 DAXX DISC1 DNAAF19 DRC4 DUSP26 EHHADH ELOA ENKD1 FAM161A FAM50B FAM90A1 FXR1 GRIA1 GRIP1 GRM7 HDAC4 HSPB1 ING4 ING5 LNX1 MAP3K1 MEOX2 MFAP1 MLLT6 NUAK2 PIBF1 PKP2 PPP1R18 PRPF18 PSMB1 RAB4A RCOR3 SMAD2 SMARCE1 SMURF1 SNAPC5 SNW1 SPP1 STAP1 TBC1D30 TCEA2 TEPSIN TES TRAF2 TSGA10IP TSHZ2 TSNAX TTC23 UBC USP2 ZMAT2 ZNF219 ZNF250 ZNF35 ZNF835	183 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AIRIM AKAP6 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BRD1 C8orf33 CARD9 CATSPERT CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57L1 CEP63 CFAP206 CIT CLU COL4A1 CRMP1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DMD DNAJC7 DPYSL2 DPYSL3 DRC4 DST DYNC1H1 EEF2 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76
Entrez ID		56850	27185
HPRD ID		02325	05553
Ensembl ID		ENSG00000068400	ENSG00000162946
Uniprot IDs		Q4V328	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs			5V4B
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding DNA Replication-dependent Chromatin Disassembly	Cytoskeleton Centrosome Microtubule Cytoplasm Microtubule-based Process Protein Binding Microtubule Cytoskeleton Organization Organelle Organization Cytosol Cytoskeleton-dependent Intracellular Transport Cytoskeleton Organization Microtubule-based Movement Microtubule Binding Transport Along Microtubule Microtubule-based Transport Organelle Localization Axo-dendritic Transport Identical Protein Binding Axonal Transport Kinesin Complex Regulation Of Microtubule-based Process Regulation Of Organelle Organization Retrograde Axonal Transport Cell Projection Organization Cell Projection Assembly Cytoskeletal Anchor Activity Regulation Of Cellular Component Organization Developmental Process Cilium Axon Cytoplasm Cell Projection Tau Protein Binding Plasma Membrane Bounded Cell Projection Assembly Ciliary Basal Body Ciliary Tip Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Centriole Structural Constituent Of Cytoskeleton Microtubule Nucleation Nervous System Development Dihydropyrimidinase Activity Cilium Organization Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Synapse Ubiquitin Protein Ligase Binding Plasma Membrane Bounded Cell Projection Organization Establishment Of Organelle Localization
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