GRIPAP1 and NUAK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRIPAP1	NUAK2
Description		GRIP1 associated protein 1	NUAK family kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Membrane Axon Dendrite Early Endosome Membrane Presynaptic Membrane Cell Projection Neuronal Cell Body Synapse Recycling Endosome Membrane Blood Microparticle Glutamatergic Synapse Extrinsic Component Of Postsynaptic Early Endosome Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Transport Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Negative Regulation Of Protein Localization Negative Regulation Of Receptor Clustering	Protein Phosphorylation Apoptotic Process Actin Cytoskeleton Organization Protein Localization To Nucleus Regulation Of Hippo Signaling Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 29403010) Meat-related diet ( 32066663) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		70 interacting genes: AARD ANKRD11 ARL15 ATG5 BYSL CASP3 CBX8 CCDC185 CCDC187 CCNH CCNT1 CDC37 CEP57L1 CFAP53 CWF19L2 DAXX DISC1 DNAAF19 DRC4 DUSP26 EHHADH ELOA ENKD1 FAM161A FAM50B FAM90A1 FXR1 GRIA1 GRIP1 GRM7 HDAC4 HSPB1 ING4 ING5 LNX1 MAP3K1 MEOX2 MFAP1 MLLT6 NUAK2 PIBF1 PKP2 PPP1R18 PRPF18 PSMB1 RAB4A RCOR3 SMAD2 SMARCE1 SMURF1 SNAPC5 SNW1 SPP1 STAP1 TBC1D30 TCEA2 TEPSIN TES TRAF2 TSGA10IP TSHZ2 TSNAX TTC23 UBC USP2 ZMAT2 ZNF219 ZNF250 ZNF35 ZNF835	7 interacting genes: ACVR1 APP GRIPAP1 LATS1 SMAD2 SMAD4 TGFBR1
Entrez ID		56850	81788
HPRD ID		02325	12172
Ensembl ID		ENSG00000068400	ENSG00000163545
Uniprot IDs		Q4V328	B4E0Y5 Q9H093
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding DNA Replication-dependent Chromatin Disassembly	Activin Receptor Signaling Pathway Cell Fate Commitment SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Ameboidal-type Cell Migration Embryonic Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ventricular Septum Morphogenesis Activin Responsive Factor Complex Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation Mesoderm Development In Utero Embryonic Development Transforming Growth Factor Beta Receptor Activity, Type I Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Anatomical Structure Morphogenesis Response To Transforming Growth Factor Beta Cardiac Septum Morphogenesis Activin Receptor Complex Activin Receptor Activity, Type I SMAD Protein Complex Trophoblast Cell Migration Roof Of Mouth Development Heteromeric SMAD Protein Complex Positive Regulation Of Signal Transduction Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cell Differentiation Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Positive Regulation Of Cell Communication Activin Binding Positive Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Epithelial Cell Differentiation Tissue Morphogenesis Secondary Palate Development
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