MDH1 and FUS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MDH1	FUS
Gene Name		malate dehydrogenase 1, NAD (soluble)	FUS RNA binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Centrosome Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Malic Enzyme Activity L-malate Dehydrogenase Activity Diiodophenylpyruvate Reductase Activity NAD Binding	Nucleotide Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Pathogenesis Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 2\'-Monophosphoadenosine 5\'-Diphosphoribose
Diseases
GWAS
Protein-Protein Interactions		7 interactors: EGFR FUS GPD1 MPP3 TERF1 TERF2IP TP53	39 interactors: ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 PA2G4 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SUV39H1 TAF15 TARDBP TDRD3 THRA TNIP1 WBP4 YBX1 ZMYM2
Entrez ID		4190	2521
HPRD ID		01100	00660
Ensembl ID		ENSG00000014641	ENSG00000089280
Uniprot IDs		P40925	P35637 Q13344 Q6IBQ5
PDB IDs			2LA6 2LCW 4FDD 4FQ3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of DNA Replication Regulation Of Telomere Maintenance RNA-dependent DNA Replication Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Cycle Negative Regulation Of DNA Replication Cellular Response To Drug Regulation Of DNA Repair Regulation Of Mitotic Cell Cycle Cell Aging Negative Regulation Of Cell Cycle Telomere Maintenance Response To Osmotic Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Chromosome Organization Alkanesulfonate Metabolic Process Glycerophosphate Shuttle Negative Regulation Of DNA Recombination At Telomere Nucleobase-containing Compound Metabolic Process Response To Drug Regulation Of Fibroblast Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Macromitophagy Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Oligodendrocyte Apoptotic Process Astrocyte Activation Regulation Of Response To DNA Damage Stimulus Response To UV Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrial Transport Negative Regulation Of Helicase Activity Telomeric Loop Formation Age-dependent Telomere Shortening Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Circadian Rhythm Positive Regulation Of Protein Complex Assembly Telomere Maintenance Via Telomere Shortening	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process RNA Splicing Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process MRNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Splicing Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription, DNA-templated MRNA Export From Nucleus RNA Export From Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?