Wiki-Pi
About
Search
People
Updates
Search
MDH1 and HSD17B10
Number of citations of the paper that reports this interaction (PubMedID
22496890
)
28
Data Source:
BioGRID
(two hybrid)
MDH1
HSD17B10
Description
malate dehydrogenase 1
hydroxysteroid 17-beta dehydrogenase 10
Image
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Centrosome
Cytosol
Extracellular Exosome
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Mitochondrial Ribonuclease P Complex
Mitochondrial Nucleoid
TRNA Methyltransferase Complex
Molecular Function
Catalytic Activity
Malic Enzyme Activity
Protein Binding
Oxidoreductase Activity
Malate Dehydrogenase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
L-malate Dehydrogenase (NAD+) Activity
Diiodophenylpyruvate Reductase (NAD+) Activity
(2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity
TRNA Binding
RNA Binding
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity
Protein Binding
Cholate 7-alpha-dehydrogenase (NAD+) Activity
Oxidoreductase Activity
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Biological Process
Tricarboxylic Acid Cycle
Oxaloacetate Metabolic Process
Malate Metabolic Process
NADP+ Metabolic Process
NAD+ Metabolic Process
Carboxylic Acid Metabolic Process
Malate-aspartate Shuttle
L-isoleucine Catabolic Process
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Beta-oxidation
Bile Acid Biosynthetic Process
Mitochondrion Organization
TRNA Processing
Steroid Metabolic Process
C21-steroid Hormone Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Protein Homotetramerization
Brexanolone Metabolic Process
Mitochondrial TRNA Methylation
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Pathways
Malate-aspartate shuttle
tRNA processing in the mitochondrion
tRNA modification in the mitochondrion
Branched-chain amino acid catabolism
rRNA processing in the mitochondrion
Mitochondrial protein degradation
Drugs
NADH
Nicotinamide adenine dinucleotide phosphate
Artenimol
NADH
1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Omega-3-carboxylic acids
Diseases
Non-syndromic X-linked mental retardation
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
GWAS
Asthma and attention deficit hyperactivity disorder (
31619474
)
Blood protein levels (
30072576
)
Smoking status (ever vs never smokers) (
30643258
)
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Interacting Genes
15 interacting genes:
CDC42
CHRM2
EGFR
ERBB2
FUS
GPD1
HSD17B10
HSPB2
LTB4R2
MPP3
SERPINB5
TERF1
TERF2IP
TP53
TTC3
30 interacting genes:
ALDH3B1
ALDOA
APP
ATP5F1A
CDC42
CHD3
CPS1
CS
ETFDH
FAF1
GLUD1
GLUL
HADHA
HADHB
HMGCL
HMGCS2
HTRA2
MDH1
OGDH
PDHB
PDHX
PTEN
PYGL
TOMM20
TOMM22
TOMM40
TRAF3IP2
TRAF5
TRAF6
UBE2D1
Entrez ID
4190
3028
HPRD ID
01100
02223
Ensembl ID
ENSG00000014641
ENSG00000072506
Uniprot IDs
A0A5K1VW95
P40925
V9HWF2
A0A0S2Z410
Q99714
PDB IDs
7RM9
7RRL
1SO8
1U7T
2O23
7ONU
8CBK
8CBL
8CBM
8CBO
8RR1
8RR3
8RR4
9EY0
9EY1
9EY2
9GCH
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Telomere Maintenance
Shelterin Complex
Regulation Of DNA Metabolic Process
ERBB2-EGFR Signaling Pathway
Nuclear Telomere Cap Complex
Negative Regulation Of Chromosome Organization
Telomere Capping
G-rich Strand Telomeric DNA Binding
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of DNA Metabolic Process
Regulation Of Telomere Maintenance
Regulation Of DNA Replication
Negative Regulation Of Telomere Maintenance Via Telomerase
Telomere Maintenance Via Telomerase
ERBB2 Signaling Pathway
Negative Regulation Of DNA Metabolic Process
Negative Regulation Of DNA Replication
RNA-templated DNA Biosynthetic Process
Regulation Of Epithelial Cell Proliferation
Gland Morphogenesis
Telomere Maintenance Via Telomere Lengthening
Telomeric DNA Binding
Negative Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Cell Growth
Regulation Of Cell Growth
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Organelle Organization
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Multivesicular Body, Internal Vesicle Lumen
Molecular Condensate Scaffold Activity
Glycerol-3-phosphate Dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Cholate 7-alpha-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Helicase Activity
Negative Regulation Of G1 To G0 Transition
Transmembrane Receptor Protein Tyrosine Kinase Activity
Response To Epidermal Growth Factor
Regulation Of Cellular Response To Stress
Regulation Of Telomere Maintenance Via Telomere Lengthening
Regulation Of DNA Repair
Mitochondrion
Organic Acid Metabolic Process
Carboxylic Acid Metabolic Process
Small Molecule Metabolic Process
Mitochondrial Matrix
TOM Complex
Tricarboxylic Acid Cycle
Mitochondrial Outer Membrane Translocase Complex
CD40 Signaling Pathway
Interleukin-17-mediated Signaling Pathway
CD40 Receptor Complex
Protein Insertion Into Mitochondrial Outer Membrane
Catabolic Process
Carboxylic Acid Catabolic Process
Organophosphate Metabolic Process
Oxidoreductase Activity
Glutamine Metabolic Process
Pyruvate Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex
Mitochondrial Inner Membrane
Protein Import Into Mitochondrial Matrix
Lipid Metabolic Process
Monocarboxylic Acid Metabolic Process
Protein Transmembrane Transporter Activity
Generation Of Precursor Metabolites And Energy
Purine-containing Compound Metabolic Process
Catalytic Activity
Dicarboxylic Acid Metabolic Process
Protein Targeting To Mitochondrion
Acyl-CoA Metabolic Process
Acetyl-CoA Metabolic Process
Protein Insertion Into Mitochondrial Membrane
Establishment Of Protein Localization To Mitochondrial Membrane
Ketone Body Biosynthetic Process
Mitochondrion Targeting Sequence Binding
Organophosphate Biosynthetic Process
Cytoplasmic Side Of Plasma Membrane
Nucleoside Phosphate Metabolic Process
Acetyl-CoA C-acetyltransferase Activity
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Interleukin-17A-mediated Signaling Pathway
Protein Localization To Mitochondrion
Neuron Projection Organization
Enoyl-CoA Hydratase Activity
Pyruvate Decarboxylation To Acetyl-CoA
Sulfur Compound Metabolic Process
Midgut Development
Mitochondrial Nucleoid
L-glutamate Catabolic Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?