MDH1 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		MDH1	TTC3
Description		malate dehydrogenase 1	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Centrosome Cytosol Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Catalytic Activity Malic Enzyme Activity Protein Binding Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADP+ Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Malate-aspartate shuttle
Drugs		NADH Nicotinamide adenine dinucleotide phosphate Artenimol
Diseases
GWAS		Asthma and attention deficit hyperactivity disorder ( 31619474) Blood protein levels ( 30072576) Smoking status (ever vs never smokers) ( 30643258)	Eye color traits ( 20463881)
Interacting Genes		15 interacting genes: CDC42 CHRM2 EGFR ERBB2 FUS GPD1 HSD17B10 HSPB2 LTB4R2 MPP3 SERPINB5 TERF1 TERF2IP TP53 TTC3	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		4190	7267
HPRD ID		01100	03773
Ensembl ID		ENSG00000014641	ENSG00000182670
Uniprot IDs		A0A5K1VW95 P40925 V9HWF2	H7BZ57 P53804
PDB IDs		7RM9 7RRL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Shelterin Complex Regulation Of DNA Metabolic Process ERBB2-EGFR Signaling Pathway Nuclear Telomere Cap Complex Negative Regulation Of Chromosome Organization Telomere Capping G-rich Strand Telomeric DNA Binding Regulation Of Phosphorus Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase ERBB2 Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Regulation Of Epithelial Cell Proliferation Gland Morphogenesis Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Regulation Of Cell Growth Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Organelle Organization Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Multivesicular Body, Internal Vesicle Lumen Molecular Condensate Scaffold Activity Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cellular Response To Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Repair	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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