MDH1 and GPD1

Number of citations of the paper that reports this interaction (PubMedID 10190973)
0

Data Source:
HPRD (in vitro)

		MDH1	GPD1
Description		malate dehydrogenase 1	glycerol-3-phosphate dehydrogenase 1
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Centrosome Cytosol Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Malic Enzyme Activity Protein Binding Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity NAD Binding Glycerol-3-phosphate Dehydrogenase (NAD+) Activity
	Biological Process	Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADP+ Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle	Carbohydrate Metabolic Process Glycerol-3-phosphate Metabolic Process Gluconeogenesis Glycerol-3-phosphate Shuttle Positive Regulation Of Glycolytic Process Glycerol-3-phosphate Catabolic Process Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor
Pathways		Malate-aspartate shuttle	Synthesis of PA
Drugs		NADH Nicotinamide adenine dinucleotide phosphate Artenimol	NADH Metformin
Diseases
GWAS		Asthma and attention deficit hyperactivity disorder ( 31619474) Blood protein levels ( 30072576) Smoking status (ever vs never smokers) ( 30643258)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: CDC42 CHRM2 EGFR ERBB2 FUS GPD1 HSD17B10 HSPB2 LTB4R2 MPP3 SERPINB5 TERF1 TERF2IP TP53 TTC3	7 interacting genes: FAM25A FAM25C FAM25G GK MDH1 POMP PTN
Entrez ID		4190	2819
HPRD ID		01100	00714
Ensembl ID		ENSG00000014641	ENSG00000167588
Uniprot IDs		A0A5K1VW95 P40925 V9HWF2	A0A024R138 P21695
PDB IDs		7RM9 7RRL	1WPQ 1X0V 1X0X 6E8Y 6E8Z 6E90 6PYP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Shelterin Complex Regulation Of DNA Metabolic Process ERBB2-EGFR Signaling Pathway Nuclear Telomere Cap Complex Negative Regulation Of Chromosome Organization Telomere Capping G-rich Strand Telomeric DNA Binding Regulation Of Phosphorus Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase ERBB2 Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Regulation Of Epithelial Cell Proliferation Gland Morphogenesis Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Regulation Of Cell Growth Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Organelle Organization Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Multivesicular Body, Internal Vesicle Lumen Molecular Condensate Scaffold Activity Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cellular Response To Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Repair	Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Intermediate Filament Polymerization Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity Intermediate Filament Polymerization Or Depolymerization Dendrite Regeneration L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Ossification Involved In Bone Remodeling Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Malic Enzyme Activity
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