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FAM214A and LIG4
Number of citations of the paper that reports this interaction (PMID
22990118
)
7
Data Source:
BioGRID
(two hybrid)
FAM214A
LIG4
Gene Name
family with sequence similarity 214, member A
ligase IV, DNA, ATP-dependent
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Condensed Chromosome
Nucleus
Nucleoplasm
Cytoplasm
Plasma Membrane
Focal Adhesion
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Nonhomologous End Joining Complex
Molecular Function
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Ligase Activity
Metal Ion Binding
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Ligation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle
Central Nervous System Development
Cell Proliferation
Response To X-ray
Response To Gamma Radiation
Viral Process
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
DNA Ligation Involved In DNA Recombination
DNA Ligation Involved In DNA Repair
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
DNA Biosynthetic Process
Establishment Of Integrated Proviral Latency
Pathways
HIV Life Cycle
Nonhomologous End-joining (NHEJ)
HIV Infection
Integration of provirus
Double-Strand Break Repair
2-LTR circle formation
Early Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Protein-Protein Interactions
8 interactors:
APC
GOLGA2
KRT40
LIG4
MAGEA6
MID2
SSX2IP
TRIM27
103 interactors:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATP6V0D1
ATR
B9D1
CAP1
CCDC176
CLU
COL1A2
COMMD1
COX1
COX2
COX3
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FAM214A
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
ND1
ND4
ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
Entrez ID
56204
3981
HPRD ID
10965
03500
Ensembl ID
ENSG00000047346
ENSG00000174405
Uniprot IDs
Q32MH5
P49917
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Transcription
Regulation Of Viral Release From Host Cell
T Cell Differentiation In Thymus
Somatic Stem Cell Maintenance
Regulation Of Viral Transcription
Negative Regulation Of Viral Process
DNA Ligation Involved In DNA Recombination
Positive Regulation Of Protein Polymerization
Negative Regulation Of Interleukin-2 Secretion
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Regulation Of Locomotion
Stem Cell Maintenance
T Cell Differentiation
Regulation Of Viral Process
Positive Regulation Of Protein Complex Assembly
Negative Regulation Of Odontogenesis
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Calcium Ion Import
Lagging Strand Elongation
Pro-B Cell Differentiation
Intraciliary Transport Involved In Cilium Morphogenesis
Negative Regulation Of Protein Kinase Activity
Immune System Process
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Negative Regulation Of Kinase Activity
Lymphocyte Differentiation
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Protein Localization To Microtubule
Establishment Of Integrated Proviral Latency
Stem Cell Development
Interferon-gamma Secretion
Immunoglobulin V(D)J Recombination
Establishment Of Viral Latency
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
T Cell Receptor V(D)J Recombination
DNA Ligation Involved In DNA Repair
Negative Regulation Of Transferase Activity
Cytoskeleton Organization
Stem Cell Differentiation
Positive Regulation Of Cellular Component Biogenesis
Lymphoid Progenitor Cell Differentiation
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Protein Phosphorylation
Leukocyte Cell-cell Adhesion
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Organelle Organization
DNA Metabolic Process
Positive Regulation Of Ligase Activity
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Double-strand Break Repair
DNA Repair
DNA Recombination
Cellular Response To Stress
Metabolic Process
Cell Cycle Process
Positive Regulation Of Protein Ubiquitination
Cellular Response To DNA Damage Stimulus
Response To Stress
Regulation Of Protein Catabolic Process
Cell Cycle Checkpoint
Mitochondrial Electron Transport, NADH To Ubiquinone
Mitotic Cell Cycle Checkpoint
Positive Regulation Of Signal Transduction By P53 Class Mediator
Viral Process
Response To Radiation
Mitotic Cell Cycle Process
Protein Metabolic Process
Negative Regulation Of Cell Cycle
Response To Gamma Radiation
Posttranscriptional Regulation Of Gene Expression
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Respiratory Electron Transport Chain
Mitochondrial ATP Synthesis Coupled Electron Transport
Regulation Of Translation
Double-strand Break Repair Via Nonhomologous End Joining
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Cell Cycle
Electron Transport Chain
Regulation Of Protein Ubiquitination
Regulation Of Response To DNA Damage Stimulus
Cell Cycle
V(D)J Recombination
Pro-B Cell Differentiation
Cellular Protein Metabolic Process
Generation Of Precursor Metabolites And Energy
Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud
?
ageing
ascribes
atm
attrition
brca1
complexity
ctip
ends
fusions
homologous
instability
insufficient
joining
ku70
lig3
mechanistically
nhej
overhang
parp1
rampant
relies
repeats
telomere
telomeres
telomeric
trf2
unanticipated
uncapped
underlining
Tagcloud (Difference)
?
ageing
ascribes
atm
attrition
brca1
complexity
ctip
ends
fusions
homologous
instability
insufficient
joining
ku70
lig3
mechanistically
nhej
overhang
parp1
rampant
relies
repeats
telomere
telomeres
telomeric
trf2
unanticipated
uncapped
underlining
Tagcloud (Intersection)
?