MAP2K6 and PKN1

Number of citations of the paper that reports this interaction (PMID 12761180)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		MAP2K6	PKN1
Gene Name		mitogen-activated protein kinase kinase 6	protein kinase N1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Ischemia Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Pathogenesis Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Positive Regulation Of Prostaglandin Secretion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Sorbitol	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Oxidative Stress Induced Senescence Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling
Drugs
Diseases
GWAS		Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225)
Protein-Protein Interactions		21 interactors: DCTN1 LRRK2 MAP2K4 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 PKN1 PLCB2 RELA SMAD7 STAT4 TAOK2 TLR3 TRAF6 ZAK	40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282
Entrez ID		5608	5585
HPRD ID		03155	03019
Ensembl ID			ENSG00000123143
Uniprot IDs		A8K3Y2 P52564	Q16512
PDB IDs		2Y8O 3ENM 3FME 3VN9	1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Intracellular Signal Transduction Activation Of Protein Kinase Activity Activation Of MAPK Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Protein Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of Phosphorylation Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Catalytic Activity Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Stress Regulation Of Catalytic Activity	Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c	accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Difference) ?		camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c	accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Intersection) ?