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MAP2K6
Gene Name
mitogen-activated protein kinase kinase 6
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytosol
Cytoskeleton
Molecular Function
Receptor Signaling Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Biological Process
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Response To Ischemia
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle Arrest
Signal Transduction
Pathogenesis
Peptidyl-tyrosine Phosphorylation
Ovulation Cycle Process
Positive Regulation Of Prostaglandin Secretion
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Response To Drug
Muscle Cell Differentiation
Positive Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Muscle Cell Differentiation
Stress-activated MAPK Cascade
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Cardiac Muscle Contraction
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Sorbitol
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
activated TAK1 mediates p38 MAPK activation
Innate Immune System
CDO in myogenesis
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Myogenesis
Oxidative Stress Induced Senescence
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Interleukin-1 signaling
Drugs
Diseases
GWAS
Response to TNF-alpha inhibitors in rheumatoid arthritis (
22569225
)
Protein-protein Interactions
21 interactors:
DCTN1
LRRK2
MAP2K4
MAP3K4
MAP3K5
MAP3K7
MAPK1
MAPK12
MAPK13
MAPK14
MAPKAPK2
MLH1
PKN1
PLCB2
RELA
SMAD7
STAT4
TAOK2
TLR3
TRAF6
ZAK
Entrez ID
5608
HPRD ID
03155
Ensembl ID
Uniprot IDs
A8K3Y2
P52564
PDB IDs
2Y8O
3ENM
3FME
3VN9
Enriched GO Terms of Interacting Partners
?
MAPK Cascade
Signal Transduction By Phosphorylation
Intracellular Signal Transduction
Activation Of Protein Kinase Activity
Activation Of MAPK Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Transferase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Protein Phosphorylation
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Stress-activated MAPK Cascade
Regulation Of MAP Kinase Activity
Regulation Of Protein Phosphorylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of MAPK Cascade
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of JNK Cascade
Positive Regulation Of Phosphorylation
Phosphorylation
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Catalytic Activity
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Signal Transduction
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor Signaling Pathway
Phosphate-containing Compound Metabolic Process
Regulation Of Phosphorus Metabolic Process
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Cellular Response To Stress
Regulation Of Catalytic Activity
Tagcloud
?
camk1
centriole
dkk1
enah
endosome
geo
gpsm2
inference
kcnq3
kpna2
lcn2
lef1
lysosome
multivesicular
nkx2
nr5a1
nup62
ontology
phosphoinositide
sfrp4
slc4a3
sort1
sstr5
stx1a
subnetwork
tbl3
transport
tshb
ube2c