MAP2K6 and STAT4

Number of citations of the paper that reports this interaction (PMID 10961885)
25

Data Source:
HPRD (in vitro, in vivo)

		MAP2K6	STAT4
Gene Name		mitogen-activated protein kinase kinase 6	signal transducer and activator of transcription 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton	Nucleoplasm Cytoplasm
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Ischemia Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Pathogenesis Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Positive Regulation Of Prostaglandin Secretion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Sorbitol	Transcription, DNA-templated Protein Phosphorylation JAK-STAT Cascade Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Oxidative Stress Induced Senescence Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling
Drugs
Diseases
GWAS		Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225)	Behcet's disease ( 23001997 23291587) Celiac disease and Rheumatoid arthritis ( 21383967) Hepatocellular carcinoma (hepatitis B virus related) ( 23242368) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Primary biliary cirrhosis ( 23000144 21399635) Rheumatoid arthritis ( 20453841 20453842) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		21 interactors: DCTN1 LRRK2 MAP2K4 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 PKN1 PLCB2 RELA SMAD7 STAT4 TAOK2 TLR3 TRAF6 ZAK	13 interactors: ADRB2 CREBBP IFNGR1 IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 STAT3 UBC ZNF467
Entrez ID		5608	6775
HPRD ID		03155	02779
Ensembl ID			ENSG00000138378
Uniprot IDs		A8K3Y2 P52564	Q14765
PDB IDs		2Y8O 3ENM 3FME 3VN9
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Intracellular Signal Transduction Activation Of Protein Kinase Activity Activation Of MAPK Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Protein Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of Phosphorylation Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Catalytic Activity Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Stress Regulation Of Catalytic Activity	Defense Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor Signaling Pathway Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cell Communication RNA Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Activation Of Innate Immune Response Response To Cytokine Cellular Response To Organic Substance Immune Response Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Positive Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Immune Response Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Signaling Cell Surface Receptor Signaling Pathway MAPK Cascade Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c	activate activated activating autocrine bind capable clear cytotoxicity distinct enhances exerts ifn il induces leads mitogen nk occur occurs populations primarily resting similarity stat1 stat5 underlie unique uniquely
Tagcloud (Difference) ?		camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c	activate activated activating autocrine bind capable clear cytotoxicity distinct enhances exerts ifn il induces leads mitogen nk occur occurs populations primarily resting similarity stat1 stat5 underlie unique uniquely
Tagcloud (Intersection) ?