MAP2K6 and RASSF1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K6	RASSF1
Description		mitogen-activated protein kinase kinase 6	Ras association domain family member 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity	Protein Binding Zinc Ion Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Apoptotic Process Signal Transduction Stress-activated Protein Kinase Signaling Cascade Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway P38MAPK Cascade Signal Transduction In Response To DNA Damage Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Protein Maturation Regulation Of Cell Cycle Cardiac Muscle Contraction Bone Development Pyroptotic Inflammatory Response Cellular Response To UV-B Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly	DNA Damage Response Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition
Pathways		NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling PKR-mediated signaling
Drugs		Fostamatinib Pimasertib
Diseases			Nasopharyngeal cancer Non-small cell lung cancer Bladder cancer
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)	Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EIF2AK2 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6	68 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SMARCA4 STK11 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA
Entrez ID		5608	11186
HPRD ID		03155	05470
Ensembl ID		ENSG00000108984	ENSG00000068028
Uniprot IDs		A8K3Y2 P52564	Q9NS23
PDB IDs		2Y8O 3ENM 3FME 3VN9 5ETF 8A8M 8P7J 8PM3	2KZU
Enriched GO Terms of Interacting Partners?		MAPK Cascade Intracellular Signal Transduction Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stress ATP Binding Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Stress-activated MAPK Cascade Nucleotide Binding P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Macromolecule Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Response To Cytokine Protein Phosphorylation Response To Peptide Positive Regulation Of MAPK Cascade Phosphorylation JNK Cascade Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAP Kinase Activity Regulation Of Immune System Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Cell Death	Regulation Of Cell Cycle Intracellular Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Protein Serine Kinase Activity Response To UV Regulation Of Signal Transduction By P53 Class Mediator Signal Transduction Regulation Of Mitotic Cell Cycle Response To Radiation Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Cellular Response To UV Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Programmed Cell Death Nucleotide Binding Cell Death Cellular Response To Light Stimulus Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Response To Light Stimulus Apoptotic Process Apoptotic Signaling Pathway Cell Cycle Phase Transition Cellular Response To Stress Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity ATP Binding Negative Regulation Of Signal Transduction Transferase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Phase Transition
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