PHACTR3 and CAPNS2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PHACTR3	CAPNS2
Name		phosphatase and actin regulator 3	calpain small subunit 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix	Cytoplasm Cytosol Plasma Membrane Membrane Calpain Complex
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Actin Cytoskeleton Organization	None
Pathways		None	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30891314 ) Schizophrenia ( 30285260 )	Thyroid hormone levels ( 23408906 )
Interacting Genes		10 interacting genes: CAPNS2 CYB5B EEF1G MAPK6 PLPP6 PPP1CA PPP1CB TAB1 UBIAD1 UBL5	9 interacting genes: APP ARMC10 CAPN2 CMTM5 OXNAD1 PHACTR3 PPIC PRPF31 RIN1
Entrez ID		116154	84290
HPRD ID		10571	16682
Ensembl ID		ENSG00000087495	ENSG00000256812
Uniprot IDs		B7Z339 Q96KR7	Q96L46
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		PTW/PP1 Phosphatase Complex Protein Serine/threonine Phosphatase Activity Dephosphorylation Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Glycogen Metabolic Process Myosin-light-chain-phosphatase Activity Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Septin Cytoskeleton Protein Modification Process Lung Development Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Nitric-oxide Synthase Complex Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Regulation Of Circadian Rhythm Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Myosin Phosphatase Activity Endoplasmic Reticulum Membrane Calpain Complex Protein Metabolic Process Phosphoprotein Phosphatase Activity Circadian Rhythm Nitrite Reductase (NO-forming) Activity Lipid Phosphatase Activity Glycogen Granule Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Menaquinone Metabolic Process Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Lysophosphatidic Acid Phosphatase Activity RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Chromosome, Telomeric Region Positive Regulation Of CGAS/STING Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Double-strand Break Repair Via Alternative Nonhomologous End Joining	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phosphatidylcholine Biosynthetic Process Calpain Complex Protein Catabolic Process At Postsynapse Regulation Of Phosphatidylcholine Biosynthetic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress SnRNP Binding U4atac SnRNP Ribonucleoprotein Complex Localization SnoRNA Localization U4atac SnRNA Binding Regulation Of Growth Rate DNA Binding Domain Binding Positive Regulation Of Growth Rate Regulation Of Interleukin-6 Production Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Spliceosomal Tri-snRNP Complex Import Into Cell Axon Choice Point Recognition U4 SnRNA Binding