ARVCF and CDH1

Number of citations of the paper that reports this interaction (PubMedID 25468996)
54

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vivo, in vitro)

		ARVCF	CDH1
Description		ARVCF delta catenin family member	cadherin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Adherens Junction Anchoring Junction	Extracellular Region Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Cadherin Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding
	Biological Process	MRNA Processing Cell Adhesion RNA Splicing Cell-cell Adhesion	Cell Morphogenesis Desmosome Assembly Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Neuron Projection Development Cell Junction Assembly Adherens Junction Organization Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of DNA-templated Transcription Regulation Of Transport Cellular Response To Lithium Ion Response To Heparin Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Response To Gram-positive Bacterium Positive Regulation Of Protein Localization
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Lymphocyte count ( 27863252 32888494) Medication use (antihypertensives) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494 22139419) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418 30487518 28739976 28135244 27841878) Systolic blood pressure ( 30578418 30487518 27841878) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 27863252 32888494)	Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428 32341527) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Nevus count or cutaneous melanoma ( 32341527) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Ulcerative colitis ( 19915572)
Interacting Genes		6 interacting genes: CDH1 CDH15 CDH2 ERBIN LNX1 TJP1	74 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF AURKB CA9 CASP3 CASP8 CBLL1 CCNB1 CDC42 CDK8 CHEK1 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 DNMT3A EGFR ERBIN EZR FADD FARP2 FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MKI67 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM PTTG1 RAB8B RRM2 SFRP2 STX17 TMOD1 UCA1 UCHL3 VCL YES1 ZNF510
Entrez ID		421	999
HPRD ID		03778	01885
Ensembl ID		ENSG00000099889	ENSG00000039068
Uniprot IDs		C9JJX6 E9PDC3 O00192	A0A0U2ZQU7 B3GN61 P12830 Q9UII7
PDB IDs			1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL 7STZ 8H62
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell-cell Junction Assembly Catenin Complex Cell Junction Organization Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Junction Cell Junction Assembly Cadherin Binding Cell Adhesion Beta-catenin Binding Anchoring Junction Gamma-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Cell Morphogenesis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Apical Junction Complex Desmosome Postsynapse Basolateral Plasma Membrane Synapse Organization Cortical Actin Cytoskeleton Neuromuscular Junction Apical Part Of Cell Cell Adhesion Molecule Binding Synapse Assembly Positive Regulation Of Synaptic Vesicle Clustering Basal Protein Localization Calcium Ion Binding Epithelial Cell Development Neuroligin Clustering Involved In Postsynaptic Membrane Assembly ErbB-2 Class Receptor Binding Intracellular Protein Localization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Postsynaptic Density Protein 95 Clustering Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Localization To Plasma Membrane Response To Heparin Cellular Response To Indole-3-methanol Lamellipodium Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Response To Indole-3-methanol Response To Gram-positive Bacterium Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Synaptic Vesicle Clustering Protein Localization To Bicellular Tight Junction	Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Cytoplasm Focal Adhesion Cadherin Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Anchoring Junction Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Cell Cortex Negative Regulation Of Apoptotic Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Protein Metabolic Process Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Cycle Nucleus Positive Regulation Of Cell Motility Negative Regulation Of Cell Motility Cytosol Cytoskeleton Positive Regulation Of Locomotion ERBB Signaling Pathway Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Organization
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