ARVCF

Description		ARVCF delta catenin family member
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Adherens Junction Anchoring Junction
	Molecular Function	Protein Binding Cadherin Binding
	Biological Process	MRNA Processing Cell Adhesion RNA Splicing Cell-cell Adhesion
Pathways
Drugs
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Lymphocyte count ( 27863252 32888494) Medication use (antihypertensives) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494 22139419) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418 30487518 28739976 28135244 27841878) Systolic blood pressure ( 30578418 30487518 27841878) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 27863252 32888494)
Interacting Genes		6 interacting genes: CDH1 CDH15 CDH2 ERBIN LNX1 TJP1
Entrez ID		421
HPRD ID		03778
Ensembl ID		ENSG00000099889
Uniprot IDs		C9JJX6 E9PDC3 O00192
PDB IDs
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell-cell Junction Assembly Catenin Complex Cell Junction Organization Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Junction Cell Junction Assembly Cadherin Binding Cell Adhesion Beta-catenin Binding Anchoring Junction Gamma-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Cell Morphogenesis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Apical Junction Complex Desmosome Postsynapse Basolateral Plasma Membrane Synapse Organization Cortical Actin Cytoskeleton Neuromuscular Junction Apical Part Of Cell Cell Adhesion Molecule Binding Synapse Assembly Positive Regulation Of Synaptic Vesicle Clustering Basal Protein Localization Calcium Ion Binding Epithelial Cell Development Neuroligin Clustering Involved In Postsynaptic Membrane Assembly ErbB-2 Class Receptor Binding Intracellular Protein Localization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Postsynaptic Density Protein 95 Clustering Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Localization To Plasma Membrane Response To Heparin Cellular Response To Indole-3-methanol Lamellipodium Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Response To Indole-3-methanol Response To Gram-positive Bacterium Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Synaptic Vesicle Clustering Protein Localization To Bicellular Tight Junction
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