ARVCF and CDH15

Number of citations: 0 (PubMedID 11058098)
Data Source: BioGRID (pull down), HPRD (in vivo, in vitro, two hybrid)

		ARVCF	CDH15
Name		ARVCF delta catenin family member	cadherin 15
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Adherens Junction Anchoring Junction	Golgi Apparatus Plasma Membrane Caveola Adherens Junction Membrane Catenin Complex Neuromuscular Junction Extracellular Exosome
	Molecular Function	Protein Binding Cadherin Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	MRNA Processing Cell Adhesion RNA Splicing Cell-cell Adhesion	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion
Pathways		None	Adherens junctions interactions Myogenesis Myogenesis
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Non-syndromic autosomal dominant mental retardation
GWAS		Appendicular lean mass ( 33097823 ) Central corneal thickness ( 29760442 32528159 ) Lymphocyte count ( 27863252 32888494 ) Medication use (antihypertensives) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Monocyte count ( 27863252 32888494 ) Neutrophil count ( 32888494 ) Platelet count ( 27863252 32888494 22139419 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Pulse pressure ( 30578418 30487518 28739976 28135244 27841878 ) Systolic blood pressure ( 30578418 30487518 27841878 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) White blood cell count ( 27863252 32888494 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: CDH1 CDH15 CDH2 ERBIN LNX1 TJP1	12 interacting genes: ARVCF BOC CDH7 CDH9 CDON CTNNA1 CTNNB1 GNA12 JUP SGTA SGTB UBQLN2
Entrez ID		421	1013
HPRD ID		03778	00225
Ensembl ID		ENSG00000099889	ENSG00000129910
Uniprot IDs		C9JJX6 E9PDC3 O00192	P55291
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Adherens Junction Organization Cell-cell Junction Assembly Catenin Complex Cell Junction Organization Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Junction Cell Junction Assembly Cadherin Binding Cell Adhesion Beta-catenin Binding Anchoring Junction Gamma-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Cell Morphogenesis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Apical Junction Complex Desmosome Postsynapse Basolateral Plasma Membrane Synapse Organization Cortical Actin Cytoskeleton Neuromuscular Junction Apical Part Of Cell Cell Adhesion Molecule Binding Synapse Assembly Positive Regulation Of Synaptic Vesicle Clustering Basal Protein Localization Calcium Ion Binding Epithelial Cell Development Neuroligin Clustering Involved In Postsynaptic Membrane Assembly ErbB-2 Class Receptor Binding Intracellular Protein Localization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Postsynaptic Density Protein 95 Clustering Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Localization To Plasma Membrane Response To Heparin Cellular Response To Indole-3-methanol Lamellipodium Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Response To Indole-3-methanol Response To Gram-positive Bacterium Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Synaptic Vesicle Clustering Protein Localization To Bicellular Tight Junction	Catenin Complex Cell-cell Adhesion Adherens Junction Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Assembly Cell Adhesion Cadherin Binding Cell-cell Junction Organization TRC Complex Cell Junction Assembly Catenin-TCF7L2 Complex Cell-cell Adhesion Mediated By Cadherin Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Adherens Junction Organization Cell Junction Organization Zonula Adherens Flotillin Complex Alpha-catenin Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Beta-catenin Binding Plasma Membrane Epithelial Cell-cell Adhesion Positive Regulation Of ERAD Pathway Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Anchoring Junction Regulation Of Skeletal Muscle Tissue Development Regulation Of ERAD Pathway Focal Adhesion Positive Regulation Of Neuroblast Proliferation Protein Targeting To ER Cell Migration Anatomical Structure Morphogenesis Establishment Of Protein Localization To Endoplasmic Reticulum Cell Morphogenesis Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Membrane Cell-cell Junction Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Striated Muscle Tissue Development Cellular Component Assembly Detection Of Mechanical Stimulus Regulation Of Muscle Organ Development Protein-DNA Complex