PKN2 and EEF1A1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PKN2	EEF1A1
Gene Name		protein kinase N2	eukaryotic translation elongation factor 1 alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Plasma Membrane Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Histone Deacetylase Binding Poly(A) RNA Binding RNA Polymerase Binding	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Positive Regulation Of Cytokinesis Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Gene Expression Cellular Protein Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus
Pathways			HSF1 activation Translation Cellular response to heat stress Peptide chain elongation Eukaryotic Translation Elongation
Drugs
Diseases
GWAS		Height ( 20881960) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		17 interactors: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA	123 interactors: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCDC130 CCL18 CDC25A CDKN1A CKS2 COX17 CRADD CRCT1 CSRP2 DARS DIABLO DLEU1 DUSP7 DYNLL1 EIF3F EXOSC4 FAS GADD45A GADD45G GSK3B HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B KRAS LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP RAB27A RAP2A RBBP8 RFC5 RGS12 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB9 SFN SHBG SMAD2 SMAD4 SMN1 SNCA SPP1 SSR1 STAT6 STMN2 SULT1E1 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSPY1 TSPYL2 TTR UBQLN4 WARS XPO5 XRN2 YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1
Entrez ID		5586	1915
HPRD ID		03972	00559
Ensembl ID		ENSG00000065243	ENSG00000156508
Uniprot IDs		Q16513	P68104 Q6IPS9
PDB IDs			1SYW
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Kinase Activity Cell Development Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Regulation Of Endothelial Cell Migration Regulation Of T Cell Activation Cellular Response To Growth Factor Stimulus Immune System Process Regulation Of Protein Metabolic Process Response To Growth Factor Negative Regulation Of Protein Phosphorylation Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Epithelial Cell Migration Cell Projection Organization Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Lamellipodium Organization Locomotion Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cell Motility Negative Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell-cell Adhesion	Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Death Death Regulation Of Phosphorylation Developmental Process Regulation Of Phosphorus Metabolic Process Response To Stimulus Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Cell Differentiation Anatomical Structure Development Regulation Of Catalytic Activity Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Cell Death Multicellular Organismal Development Regulation Of Apoptotic Process Cellular Response To Stimulus Response To Stress Cellular Response To Growth Factor Stimulus Response To External Stimulus Positive Regulation Of Protein Modification Process Regulation Of Signaling Cellular Response To Stress Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Catalytic Activity System Development Positive Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Nervous System Development Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Kinase Activity
Tagcloud ?		abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine	akap6 atf7 atxn1 bmpr2 categorize deltan grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine	akap6 atf7 atxn1 bmpr2 categorize deltan grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?