PKN2 and EIF3G

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PKN2	EIF3G
Description		protein kinase N2	eukaryotic translation initiation factor 3 subunit G
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Cell Projection Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Anchoring Junction	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Adhesion Signal Transduction Epithelial Cell Migration Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Motility	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Viral Translational Termination-reinitiation
Pathways		RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 28869591 30598549) Height ( 25282103 31562340 20881960) Intraocular pressure ( 29617998) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Narcolepsy ( 23459209) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 27841878 30224653) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA RNF10 SUMO2	29 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA MEOX2 METTL3 MIF4GD MPHOSPH6 OGT PALS2 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14
Entrez ID		5586	8666
HPRD ID		03972	04886
Ensembl ID		ENSG00000065243	ENSG00000130811
Uniprot IDs		Q16513	O75821
PDB IDs		4CRS 4RRV 6CCY 6GBE	2CQ0 2MJC 5K0Y 6YBS 6ZMW 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8XXM 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response ERBB Signaling Pathway Lamellipodium Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of T Cell Activation Roundabout Signaling Pathway Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Lamellipodium Organization Regulation Of Lymphocyte Activation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Stress Glutamatergic Synapse Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Population Proliferation Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Cell Cortex Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cell Activation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interleukin-18-mediated Signaling Pathway Immune System Process Vascular Endothelial Cell Response To Fluid Shear Stress Protein Kinase Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Laminar Fluid Shear Stress Cellular Response To Insulin Stimulus Ruffle Membrane Regulation Of Cell Adhesion	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translational Initiation Translation Initiation Factor Activity Protein-containing Complex Assembly Protein-containing Complex Organization Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Cellular Component Assembly Regulation Of Translational Initiation Protein-RNA Complex Assembly Regulation Of Translation Viral Translational Termination-reinitiation Translation Post-transcriptional Regulation Of Gene Expression Cytoplasm IRES-dependent Viral Translational Initiation Macromolecule Metabolic Process Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process RNA Binding Cytosol Telomere Assembly Protein Tetramerization Protein Metabolic Process Nucleus Phosphoprotein Binding Cap-dependent Translational Initiation Shelterin Complex Negative Regulation Of Protein Catabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process Nuclear Telomere Cap Complex Positive Regulation Of Translation Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Telomere Capping Protein-containing Complex Establishment Of Protein Localization To Organelle Regulation Of ATP Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Body Regulation Of Purine Nucleotide Metabolic Process Regulation Of Protein Catabolic Process
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