PKN2 and MAP3K2

Number of citations of the paper that reports this interaction (PubMedID 12640115)
61

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PKN2	MAP3K2
Description		protein kinase N2	mitogen-activated protein kinase kinase kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Cell Projection Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Adhesion Signal Transduction Epithelial Cell Migration Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Motility	MAPK Cascade Intracellular Signal Transduction Cellular Response To Mechanical Stimulus
Pathways		RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Fostamatinib	Bosutinib Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 28869591 30598549) Height ( 25282103 31562340 20881960) Intraocular pressure ( 29617998) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Narcolepsy ( 23459209) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 27841878 30224653) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Protein C levels ( 28082259)
Interacting Genes		19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA RNF10 SUMO2	27 interacting genes: BIRC2 CTNNB1 IKBKG ITCH LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NFKBIA PIBF1 PKN2 SH2D2A SMURF1 SMYD3 STAMBP STUB1 USP2 WNK1 XIAP YAP1 YWHAE YWHAG YWHAZ
Entrez ID		5586	10746
HPRD ID		03972	10068
Ensembl ID		ENSG00000065243	ENSG00000169967
Uniprot IDs		Q16513	Q9Y2U5
PDB IDs		4CRS 4RRV 6CCY 6GBE	2CU1 2NPT 5EX0 5HQ8 6LDV 6LDW 6LDX 6LDY
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response ERBB Signaling Pathway Lamellipodium Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of T Cell Activation Roundabout Signaling Pathway Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Lamellipodium Organization Regulation Of Lymphocyte Activation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Stress Glutamatergic Synapse Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Population Proliferation Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Cell Cortex Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cell Activation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interleukin-18-mediated Signaling Pathway Immune System Process Vascular Endothelial Cell Response To Fluid Shear Stress Protein Kinase Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Laminar Fluid Shear Stress Cellular Response To Insulin Stimulus Ruffle Membrane Regulation Of Cell Adhesion	Intracellular Signal Transduction MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Stress Signal Transduction Protein Modification Process Positive Regulation Of Protein Metabolic Process Cytosol Protein Polyubiquitination Cytoplasm Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Transferase Activity Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Serine Kinase Activity Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway MAP Kinase Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Protein Modification Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cellular Senescence Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Protein Kinase Activity Stress-activated Protein Kinase Signaling Cascade Phosphoserine Residue Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modification-dependent Protein Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
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