PKN2 and MAP3K2

Number of citations of the paper that reports this interaction (PMID 12640115)
23

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PKN2	MAP3K2
Gene Name		protein kinase N2	mitogen-activated protein kinase kinase kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Plasma Membrane Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Histone Deacetylase Binding Poly(A) RNA Binding RNA Polymerase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Positive Regulation Of Cytokinesis Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus
Pathways
Drugs
Diseases
GWAS		Height ( 20881960) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		17 interactors: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA	25 interactors: BIRC2 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K3 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 UBC USP2 WNK1 XIAP YWHAE YWHAG YWHAZ
Entrez ID		5586	10746
HPRD ID		03972	10068
Ensembl ID		ENSG00000065243	ENSG00000169967
Uniprot IDs		Q16513	Q9Y2U5
PDB IDs			2CU1 2NPT
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Kinase Activity Cell Development Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Regulation Of Endothelial Cell Migration Regulation Of T Cell Activation Cellular Response To Growth Factor Stimulus Immune System Process Regulation Of Protein Metabolic Process Response To Growth Factor Negative Regulation Of Protein Phosphorylation Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Epithelial Cell Migration Cell Projection Organization Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Lamellipodium Organization Locomotion Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cell Motility Negative Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell-cell Adhesion	Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Signal Transduction Intracellular Signal Transduction Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Toll-like Receptor Signaling Pathway Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Death Cell Communication Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Cellular Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity JNK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Cellular Response To Stress Regulation Of Catalytic Activity
Tagcloud ?		abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine
Tagcloud (Difference) ?		abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine
Tagcloud (Intersection) ?