PKN2 and MYO9B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PKN2	MYO9B
Gene Name		protein kinase N2	myosin IXB
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Plasma Membrane Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Ruffle Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Lamellipodium Filamentous Actin Filopodium Tip Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Histone Deacetylase Binding Poly(A) RNA Binding RNA Polymerase Binding	Microfilament Motor Activity Actin Binding Rho GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding Zinc Ion Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity ATP-dependent Protein Binding ADP Binding Actin Filament Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Positive Regulation Of Cytokinesis Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility	Monocyte Chemotaxis Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Filament-based Movement ARF Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Macrophage Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Lamellipodium Morphogenesis
Pathways			Rho GTPase cycle Signaling by Rho GTPases Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Height ( 20881960) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Periodontal microbiota ( 22699663)	Height ( 20881960)
Protein-Protein Interactions		17 interactors: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA	6 interactors: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2
Entrez ID		5586	4650
HPRD ID		03972	03677
Ensembl ID		ENSG00000065243	ENSG00000099331
Uniprot IDs		Q16513	B0I1T6 Q13459 Q4LE74 Q8WVD2
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Kinase Activity Cell Development Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Regulation Of Endothelial Cell Migration Regulation Of T Cell Activation Cellular Response To Growth Factor Stimulus Immune System Process Regulation Of Protein Metabolic Process Response To Growth Factor Negative Regulation Of Protein Phosphorylation Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Epithelial Cell Migration Cell Projection Organization Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Lamellipodium Organization Locomotion Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cell Motility Negative Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell-cell Adhesion	Regulation Of Cytokinesis Positive Regulation Of Protein Glycosylation In Golgi Skeletal Muscle Fiber Adaptation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Glycosylation Regulation Of High Voltage-gated Calcium Channel Activity Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Skeletal Muscle Thin Filament Assembly Regulation Of Cell Division Muscle System Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Skeletal Myofibril Assembly Skeletal Muscle Adaptation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Protein Glycosylation Response To Metal Ion Exocytosis Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Viral Genome Replication Response To Inorganic Substance Response To Steroid Hormone Positive Regulation Of Monooxygenase Activity Skeletal Muscle Fiber Development Regulation Of Cell Cycle Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Secretion By Cell Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process
Tagcloud ?		abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?