PKN2 and MYO9B

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		PKN2	MYO9B
Name		protein kinase N2	myosin IXB
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Cell Projection Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Anchoring Junction	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Lamellipodium Perinuclear Region Of Cytoplasm Postsynaptic Actin Cytoskeleton
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding Protein Serine Kinase Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Small GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Adhesion Signal Transduction Epithelial Cell Migration Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Motility	Signal Transduction Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Lamellipodium Morphogenesis
Pathways		RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Regulation of actin dynamics for phagocytic cup formation RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle FCGR3A-mediated phagocytosis
Drugs		Fostamatinib	None
GWAS		Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 34315874 33547301 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 27841878 ) General risk tolerance (MTAG) ( 30643258 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 25282103 31562340 20881960 ) Intraocular pressure ( 29617998 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514 ) Narcolepsy ( 23459209 ) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Periodontal microbiota ( 22699663 ) Photic sneeze reflex ( 27182965 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Response to fenofibrate (LDL cholesterol levels) ( 27002377 ) Rosacea symptom severity ( 29771307 ) Serum protein levels (sST2) ( 23999434 ) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306 ) Systolic blood pressure ( 27841878 30224653 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for body mass index ( 34021172 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Asthma ( 32296059 ) Coronary artery disease ( 33020668 29212778 ) Diastolic blood pressure ( 27841878 ) Glycated hemoglobin levels ( 24647736 28898252 34059833 ) Height ( 31562340 29782485 20881960 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Night sleep phenotypes ( 27126917 ) Platelet count ( 29403010 32888494 27863252 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 27863252 ) Prostate cancer ( 29892016 ) Prostate cancer (early onset) ( 29892016 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Selective IgA deficiency ( 27723758 ) Spleen volume ( 34128465 ) Systolic blood pressure ( 30578418 27841878 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 28552196 )
Interacting Genes		19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA RNF10 SUMO2	6 interacting genes: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2
Entrez ID		5586	4650
HPRD ID		03972	03677
Ensembl ID		ENSG00000065243	ENSG00000099331
Uniprot IDs		Q16513	B0I1T6 Q13459 Q8WVD2
PDB IDs		4CRS 4RRV 6CCY 6GBE	5C5S 5HPY
GO Terms Enriched among Interactors		Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response ERBB Signaling Pathway Lamellipodium Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of T Cell Activation Roundabout Signaling Pathway Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Lamellipodium Organization Regulation Of Lymphocyte Activation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Stress Glutamatergic Synapse Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Population Proliferation Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Cell Cortex Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cell Activation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interleukin-18-mediated Signaling Pathway Immune System Process Vascular Endothelial Cell Response To Fluid Shear Stress Protein Kinase Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Laminar Fluid Shear Stress Cellular Response To Insulin Stimulus Ruffle Membrane Regulation Of Cell Adhesion	Myosin Binding Cytoplasm Cytoskeleton Lamellipodium Sarcomere Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Docking Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Division Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Regulation Of Cytokinesis Centrosome Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle-mediated Transport In Synapse Organelle Localization By Membrane Tethering Golgi Vesicle Fusion To Target Membrane Golgi Organization Midbody Exocytosis Perinuclear Region Of Cytoplasm Endomembrane System Organization Negative Regulation Of Voltage-gated Calcium Channel Activity Apical Junction Assembly Striated Muscle Thin Filament Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Neurotransmitter Receptor Transport To Postsynaptic Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane