BRK1 and NDEL1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		BRK1	NDEL1
Description		BRICK1 subunit of SCAR/WAVE actin nucleating complex	nudE neurodevelopment protein 1 like 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Axon Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Axon Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Neuron Migration Inner Cell Mass Cell Proliferation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Cell Differentiation Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Vesicle Transport Along Microtubule Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Ruffle Assembly Neuron Projection Extension
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810)
Interacting Genes		9 interacting genes: BRAP CYFIP2 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1	85 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91
Entrez ID		55845	81565
HPRD ID		12818	06340
Ensembl ID		ENSG00000254999	ENSG00000166579
Uniprot IDs		Q8WUW1	A6NIZ0 Q9GZM8
PDB IDs		3P8C 4N78 7USC 7USD 7USE	2V66
Enriched GO Terms of Interacting Partners?		SCAR Complex Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Filament Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Extension Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Actin Filament-based Process Developmental Cell Growth Regulation Of Actin Filament Polymerization Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Rac Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Cell Projection Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Small GTPase-mediated Signal Transduction Cell Projection Morphogenesis Small GTPase Binding Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Projection Assembly Cell Migration Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Insulin Receptor Signaling Pathway Developmental Growth Axo-dendritic Transport Positive Regulation Of Protein Polymerization Organelle Transport Along Microtubule Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Neurofilament Cytoskeleton Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding	Microtubule-based Process Cytoskeleton Microtubule Cell Division Kinesin Complex Microtubule Binding Microtubule Cytoskeleton Organization Cytoskeleton Organization Centrosome Nucleus Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of RNA Biosynthetic Process DNA Binding Cytoskeleton-dependent Intracellular Transport Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Maintenance Of Location In Cell Organelle Organization Kinesin Binding Maintenance Of Location Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasmic Microtubule Organization Organelle Localization Acetylcholine Receptor Activator Activity Microtubule-based Movement Regulation Of Heart Rate By Cardiac Conduction Metal Ion Binding Establishment Of Organelle Localization Regulation Of Cell Cycle Microtubule Organizing Center Organization Central Region Of Growth Cone Protein Binding Cardiac Conduction Protein Kinase C Binding Retrograde Axonal Transport Presynapse Kinetochore Supramolecular Fiber Organization Maintenance Of Protein Location In Cell Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Motor Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?