BRK1 and NCKAP1

Number of citations of the paper that reports this interaction (PubMedID 8605018)
0

Data Source:
HPRD (in vivo, in vitro)

		BRK1	NCKAP1
Description		BRICK1 subunit of SCAR/WAVE actin nucleating complex	NCK associated protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Ruffle Cytosol Plasma Membrane Focal Adhesion Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Cell Projection Extracellular Exosome Postsynapse
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding Small GTPase Binding
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Morphogenesis In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Notochord Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Basal Protein Localization Apical Protein Localization Paraxial Mesoderm Development Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		9 interacting genes: BRAP CYFIP2 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1	16 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 TMEM132D WASF1 WASF2 WEE2-AS1 YWHAG
Entrez ID		55845	10787
HPRD ID		12818	05353
Ensembl ID		ENSG00000254999	ENSG00000061676
Uniprot IDs		Q8WUW1	A0A994J4I5 A0A994J6K9 Q9Y2A7
PDB IDs		3P8C 4N78 7USC 7USD 7USE	3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		SCAR Complex Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Filament Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Extension Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Actin Filament-based Process Developmental Cell Growth Regulation Of Actin Filament Polymerization Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Rac Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Cell Projection Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Small GTPase-mediated Signal Transduction Cell Projection Morphogenesis Small GTPase Binding Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Projection Assembly Cell Migration Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Insulin Receptor Signaling Pathway Developmental Growth Axo-dendritic Transport Positive Regulation Of Protein Polymerization Organelle Transport Along Microtubule Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Neurofilament Cytoskeleton Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding	SCAR Complex Cell Projection Morphogenesis Cell Projection Organization Lamellipodium Organization Rac Protein Signal Transduction Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Actin Nucleation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Assembly Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Intracellular Signaling Cassette Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Intracellular Signal Transduction Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Synapse Regulation Of Lamellipodium Organization Cell Projection Assembly Actin Polymerization Or Depolymerization Signal Transduction Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Cellular Component Size Positive Regulation Of Organelle Organization Arp2/3 Complex Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Polymerization Megakaryocyte Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
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