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BRK1 and CYFIP2
Number of citations of the paper that reports this interaction (PubMedID
8605018
)
0
Data Source:
HPRD
(in vitro, in vivo)
BRK1
CYFIP2
Description
BRICK1 subunit of SCAR/WAVE actin nucleating complex
cytoplasmic FMR1 interacting protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Lamellipodium
SCAR Complex
Extracellular Exosome
Nucleus
Cytoplasm
Cytosol
Membrane
SCAR Complex
Neuron Projection
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Binding
Small GTPase Binding
Identical Protein Binding
Protein-containing Complex Binding
RNA 7-methylguanosine Cap Binding
Protein Binding
Small GTPase Binding
Biological Process
In Utero Embryonic Development
Actin Filament Organization
Regulation Of Actin Polymerization Or Depolymerization
Positive Regulation Of Lamellipodium Assembly
Rac Protein Signal Transduction
Actin Cytoskeleton Organization
Positive Regulation Of Protein-containing Complex Assembly
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Cell Motility
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cell Morphogenesis
Apoptotic Process
Cell Adhesion
Axon Guidance
Cell Projection Assembly
Regulation Of Actin Filament Polymerization
Neuron Projection Development
Positive Regulation Of Proteolysis
Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Dendrite Extension
Cell-cell Adhesion
Regulation Of Postsynapse Assembly
Pathways
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RAC1 GTPase cycle
RAC2 GTPase cycle
RAC3 GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RAC1 GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS
Arterial stiffness index (
31235810
)
Alanine aminotransferase levels (
33547301
)
Asthma (
31959851
32296059
34103634
)
Daytime sleep phenotypes (
27126917
)
FEV1 (
30804560
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Lung function (FEV1/FVC) (
28166213
30804560
)
Peak expiratory flow (
30804560
)
T-Cell Immunoglobulin and Mucin domain 1 levels (
32460577
)
Interacting Genes
9 interacting genes:
BRAP
CYFIP2
MRFAP1
NCK1
NCKAP1
NDEL1
PFDN1
PIK3R3
WASF1
22 interacting genes:
ABI1
ABI3
APBB1
BIRC3
BRK1
DNMBP
FMR1
FXR1
FXR2
GAS7
MTDH
NCK1
NCKAP1
OXTR
PLG
PRPF40A
SMAD4
TCERG1
WASF1
WASF2
YWHAG
ZC3H12A
Entrez ID
55845
26999
HPRD ID
12818
07556
Ensembl ID
ENSG00000254999
ENSG00000055163
Uniprot IDs
Q8WUW1
B7Z8N7
E7EVJ5
Q96F07
PDB IDs
3P8C
4N78
7USC
7USD
7USE
Enriched GO Terms of Interacting Partners
?
SCAR Complex
Regulation Of Supramolecular Fiber Organization
Lamellipodium Organization
Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Actin Filament Organization
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Neuron Projection Extension
Dendrite Extension
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Actin Nucleation
Regulation Of Actin Filament-based Process
Developmental Cell Growth
Regulation Of Actin Filament Polymerization
Developmental Growth Involved In Morphogenesis
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Rac Protein Signal Transduction
Positive Regulation Of Supramolecular Fiber Organization
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Cytoskeleton Organization
Positive Regulation Of Cytoskeleton Organization
Cell Projection Organization
Regulation Of Actin Nucleation
Lamellipodium Assembly
Regulation Of Cellular Component Size
Positive Regulation Of Actin Filament Polymerization
Small GTPase-mediated Signal Transduction
Cell Projection Morphogenesis
Small GTPase Binding
Regulation Of Cellular Component Organization
Intracellular Signaling Cassette
Cell Projection Assembly
Cell Migration
Plasma Membrane Bounded Cell Projection Organization
Positive Regulation Of Cell Projection Organization
Insulin Receptor Signaling Pathway
Developmental Growth
Axo-dendritic Transport
Positive Regulation Of Protein Polymerization
Organelle Transport Along Microtubule
Dendritic Transport Of Mitochondrion
Zygotic Determination Of Anterior/posterior Axis, Embryo
Basal Protein Localization
Neurofilament Cytoskeleton
Regulation Of Protein-containing Complex Assembly
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Motility
Positive Regulation Of Cap-independent Translational Initiation
Eukaryotic Initiation Factor EIF2 Binding
SCAR Complex
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Positive Regulation Of Actin Nucleation
Lamellipodium Organization
Lamellipodium
Rac Protein Signal Transduction
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cell Projection Morphogenesis
Positive Regulation Of Supramolecular Fiber Organization
Lamellipodium Morphogenesis
Positive Regulation Of Cytoskeleton Organization
Regulation Of Actin Nucleation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Lamellipodium Assembly
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Cell Projection Organization
Cell Motility
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Regulation Of Supramolecular Fiber Organization
Regulation Of Cell Projection Assembly
Regulation Of Actin Filament-based Process
Postsynapse
Cell Projection Organization
Regulation Of Lamellipodium Organization
Regulation Of Biological Quality
Regulation Of Actin Filament Organization
Cell Migration
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Synapse
Regulation Of Cell Projection Organization
Translation Regulator Activity
Positive Regulation Of Translation
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Signaling Adaptor Activity
Regulation Of Cytoskeleton Organization
Cytoplasmic Ribonucleoprotein Granule
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Component Organization
Signal Transduction
Presynapse
Positive Regulation Of Lamellipodium Organization
Lamellipodium Assembly
RNA Strand Annealing Activity
Presynaptic Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Metabolic Process
MRNA 3'-UTR Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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