BRK1 and CYFIP2

Number of citations of the paper that reports this interaction (PMID 8605018)
19

Data Source:
HPRD (in vitro, in vivo)

		BRK1	CYFIP2
Gene Name		BRICK1, SCAR/WAVE actin-nucleating complex subunit	cytoplasmic FMR1 interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome	Cytoplasm Cytosol Membrane Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Complex Binding Rac GTPase Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Protein Homotrimerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Apoptotic Process Single Organismal Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Positive Regulation Of Proteolysis Vascular Endothelial Growth Factor Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CYFIP2 DTNBP1 NCK1 NCKAP1 PFDN1 WASF1	20 interactors: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP FMR1 FXR1 FXR2 GAS7 NCK1 NCKAP1 PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A
Entrez ID		55845	26999
HPRD ID		12818	07556
Ensembl ID		ENSG00000254999	ENSG00000055163
Uniprot IDs		Q8WUW1	E7EVJ5 E7EW33 F5H583 Q96F07
PDB IDs		3P8C
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Lamellipodium Assembly Lamellipodium Organization Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Organelle Organization Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Translation In Response To Stress Basal Protein Localization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Cytoplasmic Translation Innate Immune Response Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Immune System Process Regulation Of Immune Response Zygotic Determination Of Anterior/posterior Axis, Embryo Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Nervous System Development Ras Protein Signal Transduction Regulation Of Dopamine Receptor Signaling Pathway	Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Lamellipodium Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Actin Filament-based Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cellular Component Organization Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Regulation Of Cellular Process Immune Response-regulating Signaling Pathway Cytoskeleton Organization Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Motility Lamellipodium Morphogenesis Negative Regulation Of Biosynthetic Process Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cytoskeleton Organization System Development Cell Projection Organization Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Ras Protein Signal Transduction Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Somitogenesis Cell Migration Cell Projection Morphogenesis Regulation Of Cytoskeleton Organization Negative Regulation Of Translation
Tagcloud ?		aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited	als amyotrophic beacons biomarkers creating discovered etiology fals familial fatal g93a hmsc inherited leukocyte msod1 ones path pathogenetic pave rbbp9 sals secretory share signature slpi sod1 spatiotemporal sporadic tar
Tagcloud (Difference) ?		aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited	als amyotrophic beacons biomarkers creating discovered etiology fals familial fatal g93a hmsc inherited leukocyte msod1 ones path pathogenetic pave rbbp9 sals secretory share signature slpi sod1 spatiotemporal sporadic tar
Tagcloud (Intersection) ?