BRK1 and WASF1

Number of citations of the paper that reports this interaction (PMID 12181570)
186

Data Source:
HPRD (in vitro, in vivo)

		BRK1	WASF1
Gene Name		BRICK1, SCAR/WAVE actin-nucleating complex subunit	WAS protein family, member 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome	Cytoskeleton Actin Cytoskeleton Cell Junction SCAR Complex Synapse
	Molecular Function	Protein Complex Binding Rac GTPase Binding	Actin Binding Protein Binding Protein Complex Binding Rac GTPase Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Protein Homotrimerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Protein Complex Assembly Movement Of Cell Or Subcellular Component Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CYFIP2 DTNBP1 NCK1 NCKAP1 PFDN1 WASF1	28 interactors: ABI1 ABL1 ACTB ACTG1 ACTR2 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A NCK1 NCKAP1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10
Entrez ID		55845	8936
HPRD ID		12818	05434
Ensembl ID		ENSG00000254999	ENSG00000112290
Uniprot IDs		Q8WUW1	Q92558
PDB IDs		3P8C	3P8C
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Lamellipodium Assembly Lamellipodium Organization Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Organelle Organization Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Translation In Response To Stress Basal Protein Localization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Cytoplasmic Translation Innate Immune Response Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Immune System Process Regulation Of Immune Response Zygotic Determination Of Anterior/posterior Axis, Embryo Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Nervous System Development Ras Protein Signal Transduction Regulation Of Dopamine Receptor Signaling Pathway	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Vesicle-mediated Transport Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Defense Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Actin Cytoskeleton Organization Actin Filament-based Process Immune System Process Response To Stress Signaling Blood Coagulation Cell Communication Hemostasis Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Transport Cellular Response To Stimulus Regulation Of Body Fluid Levels Locomotion Wound Healing Cell Projection Morphogenesis Cell Part Morphogenesis Cytoskeleton Organization Cell Projection Organization Response To Stimulus Response To Wounding Axonogenesis Axon Guidance Ephrin Receptor Signaling Pathway Axon Development
Tagcloud ?		aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited
Tagcloud (Difference) ?		aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited
Tagcloud (Intersection) ?