BRK1 and PFDN1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		BRK1	PFDN1
Gene Name		BRICK1, SCAR/WAVE actin-nucleating complex subunit	prefoldin subunit 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome	Prefoldin Complex
	Molecular Function	Protein Complex Binding Rac GTPase Binding	Sequence-specific DNA Binding Transcription Factor Activity Unfolded Protein Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Protein Homotrimerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Regulation Of Transcription, DNA-templated Protein Folding Cell Cycle Telencephalon Development Cerebellum Development Actin Cytoskeleton Organization B Cell Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CYFIP2 DTNBP1 NCK1 NCKAP1 PFDN1 WASF1	54 interactors: ACTA1 ACTB ALB ASNA1 BRK1 CCDC85A CHGA DCTN1 DEFA1 DGCR14 EDRF1 EIF3C EIF4A2 EOMES EXT2 EZH2 FAM20C GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 KIAA1377 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 TUBA1A YEATS4 ZNF235
Entrez ID		55845	5201
HPRD ID		12818	05357
Ensembl ID		ENSG00000254999	ENSG00000113068
Uniprot IDs		Q8WUW1	O60925
PDB IDs		3P8C
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Lamellipodium Assembly Lamellipodium Organization Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Organelle Organization Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Translation In Response To Stress Basal Protein Localization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Cytoplasmic Translation Innate Immune Response Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Immune System Process Regulation Of Immune Response Zygotic Determination Of Anterior/posterior Axis, Embryo Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Nervous System Development Ras Protein Signal Transduction Regulation Of Dopamine Receptor Signaling Pathway	Organelle Organization Cellular Localization Cellular Macromolecule Biosynthetic Process Cellular Component Assembly Macromolecule Biosynthetic Process Gene Expression Membrane Organization RNA Biosynthetic Process Cellular Protein Localization Establishment Of Protein Localization To Membrane Protein Localization Developmental Process Cerebral Cortex Regionalization Mitotic Cell Cycle Biosynthetic Process Cellular Process Cytoskeleton-dependent Intracellular Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Metabolic Process Establishment Of Localization In Cell Anatomical Structure Development RNA Metabolic Process Organelle Localization 'de Novo' Posttranslational Protein Folding Intracellular Transport Cell Cycle Process 'de Novo' Protein Folding Regulation Of Metabolic Process Telencephalon Regionalization Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Protein Localization To Organelle Positive Regulation Of Cellular Metabolic Process Protein Localization To Membrane Vesicle Localization Regulation Of Cilium Assembly Multicellular Organismal Development Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Phase Transition Anatomical Structure Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Killing Of Cells Of Other Organism Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Anatomical Structure Formation Involved In Morphogenesis
Tagcloud ?		aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited
Tagcloud (Difference) ?		aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited
Tagcloud (Intersection) ?