BRK1 and PIK3R3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		BRK1	PIK3R3
Description		BRICK1 subunit of SCAR/WAVE actin nucleating complex	phosphoinositide-3-kinase regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Cytosol Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Migration Involved In Sprouting Angiogenesis Immune Response Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Anoikis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Co-stimulation by ICOS
Drugs			SF1126
Diseases
GWAS		Arterial stiffness index ( 31235810)	Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Serum metabolite levels ( 33031748) Sodium levels ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		9 interacting genes: BRAP CYFIP2 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1	122 interacting genes: ABCB6 ABL2 AMBP ANKS1A ANTKMT AR ARID4B AUNIP AXL BLK BLZF1 BRK1 BTK C3orf36 CAMK1 CCDC14 CCDC196 CCDC33 CCDC89 CEP126 CEP19 CHRDL2 CIMIP2B CLNK CRBN CRK DARS1 DCAF8 DISC1 DRAP1 DSN1 E2F6 EGFR ENKD1 ERBB2 ERBB3 ERBB4 ESR1 FBN3 FER FGB FNDC8 FOXO1 FSD2 FYN GAB1 GC GRB2 HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 ITGB3BP KARS1 KHDRBS1 KIAA0408 KIT KLC2 KLF15 KMT2B L3MBTL3 LAP3 LNX2 LUC7L2 MBIP MECOM MET MICAL1 MTF2 NAB2 NCK1 NEBL NEDD9 ORM1 PACRGL PBX4 PCDHB5 PDGFRB PELO PIK3CA PLAAT4 PLB1 PLEKHF2 PPARA PRKAR1B PSME1 PTK2 QARS1 RB1 RING1 RUSC1 SERF1A SERTAD2 SPATA32 SPMIP6 SRC SSBP4 STAT3 STAT5B TASOR2 TEC TERF2 TNK2 TNNC2 TNNI1 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 YES1 YPEL3 ZBTB18 ZMAT1 ZNF281 ZNF451 ZNF620
Entrez ID		55845	8503
HPRD ID		12818	05831
Ensembl ID		ENSG00000254999	ENSG00000117461
Uniprot IDs		Q8WUW1	B4DXM8 Q8N381 Q92569
PDB IDs		3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		SCAR Complex Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Filament Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Extension Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Actin Filament-based Process Developmental Cell Growth Regulation Of Actin Filament Polymerization Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Rac Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Cell Projection Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Small GTPase-mediated Signal Transduction Cell Projection Morphogenesis Small GTPase Binding Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Projection Assembly Cell Migration Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Insulin Receptor Signaling Pathway Developmental Growth Axo-dendritic Transport Positive Regulation Of Protein Polymerization Organelle Transport Along Microtubule Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Neurofilament Cytoskeleton Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity ERBB Signaling Pathway Kinase Activity Phosphorylation Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Phosphorylation Ephrin Receptor Binding Positive Regulation Of Phosphate Metabolic Process Ephrin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Binding Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Response To Peptide Hormone SH2 Domain Binding Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Programmed Cell Death ATP Binding Positive Regulation Of Cell Population Proliferation Cellular Response To Peptide Hormone Stimulus Response To Platelet-derived Growth Factor Regulation Of Phosphorus Metabolic Process Cell Population Proliferation Insulin Receptor Complex Transferase Activity Positive Regulation Of Cellular Component Organization Receptor Complex Signaling Adaptor Activity Insulin Receptor Substrate Binding Regulation Of Signal Transduction Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway
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