BRK1

Gene Name		BRICK1, SCAR/WAVE actin-nucleating complex subunit
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Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Complex Binding Rac GTPase Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Protein Homotrimerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: CYFIP2 DTNBP1 NCK1 NCKAP1 PFDN1 WASF1
Entrez ID		55845
HPRD ID		12818
Ensembl ID		ENSG00000254999
Uniprot IDs		Q8WUW1
PDB IDs		3P8C
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Lamellipodium Assembly Lamellipodium Organization Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Organelle Organization Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Translation In Response To Stress Basal Protein Localization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Cytoplasmic Translation Innate Immune Response Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Immune System Process Regulation Of Immune Response Zygotic Determination Of Anterior/posterior Axis, Embryo Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Nervous System Development Ras Protein Signal Transduction Regulation Of Dopamine Receptor Signaling Pathway
Tagcloud ?		aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited