TTC27 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		TTC27	CRYAA
Description		tetratricopeptide repeat domain 27	crystallin alpha A
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process		Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Haemorrhoidal disease ( 33888516) Hippocampal atrophy ( 22745009) Intelligence (MTAG) ( 29326435) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Rosacea symptom severity ( 29771307) Upper eyelid sagging severity ( 24869959)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		8 interacting genes: ACVR1 BMPR1B CRYAA DAPK1 ITSN1 LRRK2 MFHAS1 TGFBR1	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		55622	1409
HPRD ID		08618	00427
Ensembl ID		ENSG00000018699	ENSG00000160202
Uniprot IDs		B4DRC7 Q6P3X3	A0A8C8KJZ9 P02489
PDB IDs			6T1R
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity SMAD Binding Protein Kinase Activity Activin Receptor Complex Activin Receptor Activity, Type I Kinase Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Pharyngeal System Development Negative Regulation Of Programmed Cell Death Syntaxin-1 Binding Transforming Growth Factor Beta Binding Nucleotide Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Response To Stress Ventricular Septum Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Lens Development In Camera-type Eye Growth Factor Binding Cellular Response To Growth Factor Stimulus ATP Binding Regulation Of Cell Communication Positive Regulation Of Biomineral Tissue Development Regulation Of Signaling Regionalization Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification Animal Organ Development Regulation Of Macrophage Activation Negative Regulation Of Intracellular Transport Anatomical Structure Morphogenesis Endocardial Cushion Cell Fate Commitment Dorsal/ventral Pattern Formation	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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