LOXL4 and COL2A1

Number of citations of the paper that reports this interaction (PMID 11292829)
9

Data Source:
HPRD (in vitro)

		LOXL4	COL2A1
Gene Name		lysyl oxidase-like 4	collagen, type II, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane Receptor Complex Extracellular Vesicular Exosome	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protein-lysine 6-oxidase Activity Scavenger Receptor Activity Copper Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Receptor-mediated Endocytosis Oxidation-reduction Process	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Collagen formation Crosslinking of collagen fibrils Elastic fibre formation Assembly of collagen fibrils and other multimeric structures	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AP1M2 APOE CDC37 COL2A1 ECSIT EXOC6 KDM1A LONP1 MAST1 PRMT6 RAD23A RNF32 SUV39H1 TRIP13	33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		84171	1280
HPRD ID		09538	00361
Ensembl ID		ENSG00000138131	ENSG00000139219
Uniprot IDs		Q96JB6	P02458
PDB IDs			1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Organelle Organization Protein Metabolic Process Cellular Response To Stress Response To Stress Viral Process Developmental Process Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Cellular Protein Metabolic Process Regulation Of Oxidoreductase Activity Cellular Response To DNA Damage Stimulus Cell Differentiation Regulation Of Metabolic Process Histone H3-R2 Methylation Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Histone Modification Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Chromosome Organization Cell Development DNA Metabolic Process Histone Methylation Response To Stimulus Cellular Response To Stimulus Protein Localization Cellular Metabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization Establishment Of Localization In Cell Maintenance Of Location In Cell Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Axon Development	Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis
Tagcloud ?		193a 3p bc bladder challenges chemoresistance chemoresistant chemosensitive curative drastically executes forced former formidable genbank guided insight lysyl mechanistic mir multi nr nude obstacle oxidase presents relay reversal xenografts	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Difference) ?		193a 3p bc bladder challenges chemoresistance chemoresistant chemosensitive curative drastically executes forced former formidable genbank guided insight lysyl mechanistic mir multi nr nude obstacle oxidase presents relay reversal xenografts	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Intersection) ?