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MSL2 and H2AC20
Number of citations of the paper that reports this interaction (PubMedID
21726816
)
42
Data Source:
BioGRID
(enzymatic study)
MSL2
H2AC20
Description
MSL complex subunit 2
H2A clustered histone 20
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Chromosome
MSL Complex
Nucleosome
Nucleus
Chromosome
Extracellular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Promoter-enhancer Loop Anchoring Activity
Histone H2B Ubiquitin Ligase Activity
DNA Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Biological Process
Chromatin Organization
Protein Monoubiquitination
DNA Damage Response
Protein Ubiquitination
Epigenetic Regulation Of Gene Expression
Positive Regulation Of DNA-templated Transcription
Heterochromatin Formation
Pathways
HATs acetylate histones
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
33339817
33547301
)
Alanine transaminase levels (
29403010
)
Apolipoprotein A1 levels (
32203549
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood urea nitrogen levels (
31152163
)
C-reactive protein levels (
30388399
)
Coronary artery disease (
29212778
33020668
)
Estimated glomerular filtration rate (
31152163
)
Fibrinogen (
23969696
)
HDL cholesterol levels (
32203549
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Height (
31217584
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Lipoprotein (a) levels (
33730874
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Lymphocyte percentage of white cells (
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Schizophrenia (
29483656
28991256
25056061
)
Serum alkaline phosphatase levels (
33339817
33547301
)
Triglyceride levels in current drinkers (
30698716
)
Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Interacting Genes
14 interacting genes:
APOBEC3B
H2AC18
H2AC20
H2BC21
H3C14
H4C1
PAF1
TP53
TRIM8
UBE2D3
VHL
YWHAE
YWHAG
YWHAZ
72 interacting genes:
ANP32A
APP
ATXN7L3
BAP1
BARD1
BMI1
BRCA1
CDY1
CEBPA
CRP
CSTF1
CTCFL
DDB2
DNMT3L
EIF2AK2
EP300
ESR1
FBL
GATAD2A
GATAD2B
H2BC1
H4C14
HAT1
HDAC2
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAA40
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
POT1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
STK38
TAF15
TAF1A
TAF1B
TCF20
TRIM37
TSPY1
TSSK6
UBC
UBE2B
UBE2H
UBR2
UIMC1
USP10
USP12
USP16
USP2
USP22
USP46
USP51
USP7
USP8
Entrez ID
55167
8338
HPRD ID
08550
09107
Ensembl ID
ENSG00000174579
ENSG00000184260
Uniprot IDs
Q9HCI7
Q16777
PDB IDs
4B7Y
4B86
6Y5E
7U0G
7U0I
7U0J
8DK5
8EVG
8EVH
8EVI
8EVJ
8SPS
8SPU
8SYP
Enriched GO Terms of Interacting Partners
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Protein Heterodimerization Activity
Structural Constituent Of Chromatin
Nucleosome
Nucleus
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Protein Sequestering Activity
Chromatin Remodeling
Cellular Response To Glucose Starvation
Negative Regulation Of Macromolecule Metabolic Process
Phosphoserine Residue Binding
Extracellular Exosome
Chromosome
Negative Regulation Of Metabolic Process
Negative Regulation Of TORC1 Signaling
Chromatin Organization
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of TOR Signaling
Negative Regulation Of RNA Metabolic Process
Protein Polyubiquitination
Regulation Of TORC1 Signaling
Negative Regulation Of Transcription By RNA Polymerase II
Nucleosome Assembly
Protein Ubiquitination
Protein Localization To Organelle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleosome Organization
Protein Modification By Small Protein Conjugation
Protein K6-linked Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Gene Expression
Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of TOR Signaling
Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Response To Stress
Negative Regulation Of DNA-templated Transcription
Protein Localization To Nucleus
Cellular Response To Starvation
Post-translational Protein Modification
Protein K11-linked Ubiquitination
Protein-DNA Complex Assembly
Chromatin Binding
Proteasomal Protein Catabolic Process
Protein Targeting
Negative Regulation Of Signal Transduction
Regulation Of Protein Localization
Negative Regulation Of Helicase Activity
Negative Regulation Of G1 To G0 Transition
Chromatin Organization
Chromatin Remodeling
Nucleus
Histone Binding
Nucleoplasm
Epigenetic Regulation Of Gene Expression
Chromatin Binding
Chromosome
Protein Modification Process
Macromolecule Metabolic Process
Post-translational Protein Modification
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Protein Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cellular Response To Stress
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Histone H4 Acetyltransferase Activity
Cysteine-type Deubiquitinase Activity
Negative Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Histone H2A Deubiquitinase Activity
Protein Deubiquitination
Regulation Of DNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Histone Acetyltransferase Activity
DNA Damage Response
Protein Modification By Small Protein Removal
Negative Regulation Of Biosynthetic Process
Transferase Activity
Nucleic Acid Metabolic Process
DNA Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Cysteine-type Peptidase Activity
Protein-containing Complex
Positive Regulation Of DNA-templated Transcription
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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