MARCHF1 and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 14722266)
36

Data Source:
BioGRID (pull down)

		MARCHF1	UBE2H
Description		membrane associated ring-CH-type finger 1	ubiquitin conjugating enzyme E2 H
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Trans-Golgi Network Membrane	Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity MHC Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Protein Ubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CDC34 HLA-DRA HLA-DRB1 INSR UBC UBE2D1 UBE2H	71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		55016	7328
HPRD ID		07940	03052
Ensembl ID		ENSG00000145416	ENSG00000186591
Uniprot IDs		A8K0Z6 D6RGC4 Q8TCQ1	A0A3B3IU20 A4D1L5 P62256
PDB IDs			2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Myeloid Dendritic Cell Antigen Processing And Presentation Dendritic Cell Antigen Processing And Presentation Endocytic Vesicle Membrane Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane Positive Regulation Of Memory T Cell Differentiation MHC Class II Receptor Activity Protein K48-linked Ubiquitination Regulation Of Memory T Cell Differentiation T Cell Receptor Binding Polysaccharide Binding Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Positive Regulation Of Regulatory T Cell Differentiation MHC Class II Protein Complex Binding Modification-dependent Protein Catabolic Process Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding Regulation Of Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Proteolysis Involved In Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Regulation Of T Cell Mediated Cytotoxicity Immunological Synapse Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Protein Polyubiquitination Regulation Of T-helper Cell Differentiation Transport Vesicle Membrane Positive Regulation Of Alpha-beta T Cell Differentiation ER To Golgi Transport Vesicle Membrane Protein Modification Process Post-translational Protein Modification Antigen Processing And Presentation Of Peptide Antigen Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of T Cell Mediated Immunity	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?