MARCH1 and HLA-DRA

Number of citations of the paper that reports this interaction (PMID 23264739)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MARCH1	HLA-DRA
Gene Name		membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	major histocompatibility complex, class II, DR alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane Trans-Golgi Network Membrane	Golgi Membrane Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity MHC Protein Binding	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response	Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation T Cell Receptor Signaling Pathway Cognition Interferon-gamma-mediated Signaling Pathway
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Type 2 diabetes ( 21490949)	Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Asthma ( 23028483 21804548) Complement C3 and C4 levels ( 23028341) Cystic fibrosis severity ( 21602797) Hodgkin's lymphoma ( 21037568 22286212) Lymphoma ( 23349640) Multiple sclerosis ( 17660530) Multiple sclerosis (OCB status) ( 23472185) Non-obstructive azoospermia ( 22541561) Parkinson's disease ( 20711177) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Rheumatoid arthritis ( 21653640) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 20228798 18836448 21297633 19122664) Vitiligo ( 20410501)
Protein-Protein Interactions		5 interactors: CDC34 HLA-DRA HLA-DRB1 UBE2D1 UBE2H	10 interactors: CD63 CD74 CD82 HLA-DMA HLA-DMB HLA-DRB1 HLA-DRB5 MARCH1 MBP PRPF40B
Entrez ID		55016	3122
HPRD ID		07940	00833
Ensembl ID		ENSG00000145416	ENSG00000204287
Uniprot IDs		A8K0Z6 D6RGC4 Q8TCQ1	P01903 Q30118
PDB IDs			1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4E41 4FQX 4GBX 4H1L
Enriched GO Terms of Interacting Partners?		Polysaccharide Assembly With MHC Class II Protein Complex Protein K48-linked Ubiquitination Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Protein Polyubiquitination Immune Response-regulating Signaling Pathway T Cell Costimulation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein Modification By Small Protein Conjugation Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Antigen Receptor-mediated Signaling Pathway Cellular Response To Interferon-gamma Innate Immune Response Cellular Macromolecule Catabolic Process Response To Interferon-gamma Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Positive Regulation Of Inclusion Body Assembly Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Negative Regulation Of CAMP-mediated Signaling Defense Response Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Proteolysis Regulation Of Lymphocyte Activation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Immune System Process Positive Thymic T Cell Selection Regulation Of Immune Response Positive Regulation Of Immune System Process Thymic T Cell Selection Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Regulation Of Immune System Process Regulation Of Interleukin-4 Production Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Cytokine Leukocyte Mediated Immunity T Cell Selection Adaptive Immune Response 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cellular Protein Complex Assembly Chaperone-mediated Protein Folding T Cell Costimulation T Cell Differentiation In Thymus Protein Complex Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of T Cell Differentiation Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway
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