MARCH1

Gene Name		membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane Trans-Golgi Network Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity MHC Protein Binding
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response
Pathways
Drugs
Diseases
GWAS		Type 2 diabetes ( 21490949)
Protein-protein Interactions		5 interactors: CDC34 HLA-DRA HLA-DRB1 UBE2D1 UBE2H
Entrez ID		55016
HPRD ID		07940
Ensembl ID		ENSG00000145416
Uniprot IDs		A8K0Z6 D6RGC4 Q8TCQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Polysaccharide Assembly With MHC Class II Protein Complex Protein K48-linked Ubiquitination Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Protein Polyubiquitination Immune Response-regulating Signaling Pathway T Cell Costimulation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein Modification By Small Protein Conjugation Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Antigen Receptor-mediated Signaling Pathway Cellular Response To Interferon-gamma Innate Immune Response Cellular Macromolecule Catabolic Process Response To Interferon-gamma Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Positive Regulation Of Inclusion Body Assembly Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Negative Regulation Of CAMP-mediated Signaling Defense Response Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Proteolysis Regulation Of Lymphocyte Activation
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