MARCH1 and HLA-DRB1

Number of citations of the paper that reports this interaction (PMID 23264739)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MARCH1	HLA-DRB1
Gene Name		membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	major histocompatibility complex, class II, DR beta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane Trans-Golgi Network Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity MHC Protein Binding	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Peptide Antigen Assembly With MHC Class II Protein Complex Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Type 2 diabetes ( 21490949)	Arthritis (juvenile idiopathic) ( 18576341) Cervical cancer ( 23482656) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) IgA nephropathy ( 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Leishmaniasis (visceral) ( 23291585) Lumiracoxib-related liver injury ( 20639878) Lymphoma ( 23349640) Multiple sclerosis ( 22190364 19525953 19525955 18941528) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 22086417) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Response to ximelagatran treatment ( 17505501) Rheumatoid arthritis ( 21452313 17804836 18794853 17554300 20453841 20453842) Schizophrenia ( 23212062) Systemic lupus erythematosus ( 23273568 19838193) Systemic sclerosis ( 21779181) Type 1 diabetes ( 17632545) Ulcerative colitis ( 23128233 21297633 19122664 23511034)
Protein-Protein Interactions		5 interactors: CDC34 HLA-DRA HLA-DRB1 UBE2D1 UBE2H	9 interactors: CTAG1B HLA-DMA HLA-DRA MAGEA3 MARCH1 TRA TRB TRIM21 ZDHHC17
Entrez ID		55016	3123
HPRD ID		07940	08349
Ensembl ID		ENSG00000145416	ENSG00000196126
Uniprot IDs		A8K0Z6 D6RGC4 Q8TCQ1	D7RIH8 P01911 P01912 Q29974 Q5Y7D1
PDB IDs			1A6A 1BX2 1YMM 2WBJ
Enriched GO Terms of Interacting Partners?		Polysaccharide Assembly With MHC Class II Protein Complex Protein K48-linked Ubiquitination Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Protein Polyubiquitination Immune Response-regulating Signaling Pathway T Cell Costimulation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein Modification By Small Protein Conjugation Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Antigen Receptor-mediated Signaling Pathway Cellular Response To Interferon-gamma Innate Immune Response Cellular Macromolecule Catabolic Process Response To Interferon-gamma Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Positive Regulation Of Inclusion Body Assembly Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Negative Regulation Of CAMP-mediated Signaling Defense Response Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Proteolysis Regulation Of Lymphocyte Activation	Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Interferon-gamma-mediated Signaling Pathway Immune System Process Cellular Response To Interferon-gamma Polysaccharide Assembly With MHC Class II Protein Complex Response To Interferon-gamma Protein Polyubiquitination Negative Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Activation Protein Complex Assembly Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Deubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Thymic T Cell Selection Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Viral Release From Host Cell Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Lipoprotein Transport Regulation Of Viral Entry Into Host Cell Magnesium Ion Transport Cellular Component Assembly Thymic T Cell Selection Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Cellular Protein Metabolic Process Response To Stimulus Protein Destabilization Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein Palmitoylation Protein Modification By Small Protein Conjugation Regulation Of Cell Adhesion Cellular Macromolecular Complex Assembly Positive Regulation Of Immune Response
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