WDR55 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		WDR55	CRYAA
Description		WD repeat domain 55	crystallin alpha A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function		Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	RRNA Processing	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 28991256 29483656) Serum immune biomarker levels ( 32066700)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		4 interacting genes: CRYAA CSNK2A1 OGT SRPK1	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		54853	1409
HPRD ID		08614	00427
Ensembl ID		ENSG00000120314	ENSG00000160202
Uniprot IDs		G3V1J0 Q9H6Y2	A0A8C8KJZ9 P02489
PDB IDs		7KQQ 8FKY	6T1R
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Translational Initiation Protein Localization To Vacuole Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein Catabolic Process Cell Death Positive Regulation Of Cell Growth Apoptotic Process Programmed Cell Death Cellular Component Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Translation Protein Kinase CK2 Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Macroautophagy Protein O-acetylglucosaminyltransferase Activity Protein Folding Regulation Of Proteasomal Protein Catabolic Process Protein Stabilization Response To Stress Negative Regulation Of Gene Expression Positive Regulation Of Aggrephagy Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Growth Rhythmic Process Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Lens Fiber Cell Morphogenesis Protein-containing Complex Assembly Membraneless Organelle Assembly Carbon Catabolite Regulation Of Transcription Autophagy Protein-containing Complex Organization Regulation Of Transcription By Glucose Regulation Of Programmed Cell Death Tubulin Complex Assembly Protein Serine Kinase Activity Double-strand Break Repair Via Classical Nonhomologous End Joining NSL Complex Nucleoplasm Regulation Of Protein Stability	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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