PML and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 34795231)
82

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, enzymatic study)

		PML	PIAS2
Description		PML nuclear body scaffold	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Matrix PML Body Early Endosome Membrane Nuclear Membrane	Chromatin Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Binding Identical Protein Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Molecular Adaptor Activity Ubiquitin-like Protein Ligase Activity	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Defense Response To Virus By Host Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Targeting Protein Import Into Nucleus Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Angiogenesis Protein Sumoylation Myeloid Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator PML Body Organization Protein-containing Complex Localization Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Circadian Regulation Of Gene Expression Negative Regulation Of Translation In Response To Oxidative Stress Response To Cytokine Protein Localization To Nucleus Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Cell Fate Commitment Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Retinoic Acid Receptor Signaling Pathway Rhythmic Process Protein Stabilization Regulation Of Protein Metabolic Process Maintenance Of Protein Location In Nucleus Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Cellular Localization SMAD Protein Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Protein-containing Complex Assembly Regulation Of Biological Quality Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Senescence Oncogene-induced Cell Senescence Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Localization To Chromosome, Telomeric Region Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Protein Sumoylation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Arsenic trioxide
Diseases		Acute myeloid leukemia (AML)
GWAS		Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) ( 29899525) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Height ( 20881960 25282103 28552196) Hip circumference adjusted for BMI ( 34021172) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Myopia (pathological) ( 23049088) Paget's disease ( 21623375) Physical activity (overall physical activity time) ( 30531941) White blood cell count ( 32888494)	Fruit consumption ( 32066663)
Interacting Genes		111 interacting genes: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHEK2 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 ERCC6 FOS FXR1 GATA1 GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A KLHL20 MAD1L1 MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NACC1 NCOA2 NCOR1 NCOR2 NFKB1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PSMA3 RARA RB1 RBX1 RELA RNF125 RPL11 RXRA SENP1 SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SMAD3 SNCA SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIB3 TRIM24 TRIM27 TRIM69 UBC UBE2I UBE2U UBE3A USP11 USP2 ZBTB16 ZFYVE9 ZNF451	128 interacting genes: - ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK14 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT1 STAT4 STIP1 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2
Entrez ID		5371	9063
HPRD ID		00023	06944
Ensembl ID		ENSG00000140464	ENSG00000078043
Uniprot IDs		P29590	O75928 Q2TA77
PDB IDs		1BOR 2MVW 2MWX 4WJN 4WJO 5YUF 6IMQ 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 8DJH 8DJI 8J25 8J2P 8YTC	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus PML Body Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Binding DNA-templated Transcription Apoptotic Process Transcription By RNA Polymerase II Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Cell Communication Programmed Cell Death Cell Death Regulation Of Cell Cycle Transcription Regulator Complex Intracellular Signal Transduction Chromatin Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation	Identical Protein Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Positive Regulation Of Biosynthetic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Estrogen Response Element Binding Sequence-specific DNA Binding Positive Regulation Of Metabolic Process
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