PML and RBX1

Number of citations of the paper that reports this interaction (PMID 21840486)
27

Data Source:
BioGRID (enzymatic study)

		PML	RBX1
Gene Name		promyelocytic leukemia	ring-box 1, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Early Endosome Membrane Nuclear Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding Protein Homodimerization Activity SMAD Binding Protein Heterodimerization Activity Cobalt Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Protein Complex Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Response To Hypoxia Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Targeting Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Negative Regulation Of Cell Growth PML Body Organization Positive Regulation Of Histone Deacetylation Negative Regulation Of Telomere Maintenance Via Telomerase Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Gene Expression Negative Regulation Of Translation In Response To Oxidative Stress Response To Cytokine Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Cell Fate Commitment Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Retinoic Acid Receptor Signaling Pathway Protein Stabilization Maintenance Of Protein Location In Nucleus Defense Response To Virus Negative Regulation Of Telomerase Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Interferon-gamma-mediated Signaling Pathway Branching Involved In Mammary Gland Duct Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Cellular Senescence Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	DNA Repair Protein Monoubiquitination Notch Signaling Pathway Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by ERBB4 Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection APC truncation mutants have impaired AXIN binding APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer Cytokine Signaling in Immune system Nuclear signaling by ERBB4 NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Height ( 20881960) Myopia (pathological) ( 23049088) Paget's disease ( 21623375)	Crohn's disease ( 22936669)
Protein-Protein Interactions		101 interactors: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 FOS GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NCOA2 NCOR1 NCOR2 NFKB1 NR3C1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PPARG PSMA3 RARA RB1 RBX1 RELA RNF111 RNF125 RNF4 RPL11 RXRA SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SMAD3 SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIM24 TRIM27 TRIM69 UBE2I UBE2U UBE3A ZBTB16 ZFYVE9	58 interactors: APP BRCA1 CAND1 CCND1 CCNE1 CDC34 COPS6 CSNK1E CTNNB1 CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 DDB1 FBXO18 FBXW8 FRZB GLMN GPS1 HAX1 HIST1H1C MAP3K7 MAPK8IP2 MKNK2 MYB NFKBIA OS9 PLK1 PML PRAME RHOBTB3 RNF126 RPS6KB1 SAMHD1 SERTAD1 SKP1 SMAD3 TAB1 TP73 TRIM27 TRIM74 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2M UBE2R2 VHL VPRBP VRK2 WNK1 ZAK
Entrez ID		5371	9978
HPRD ID		00023	06794
Ensembl ID		ENSG00000140464
Uniprot IDs		P29590	P62877
PDB IDs		1BOR	1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Gene Expression Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Cell Cycle	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Cell Cycle Process Cellular Response To Stimulus Cell Cycle Regulation Of Cell Cycle Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Response To Stress Regulation Of Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Modification Process Proteolysis Regulation Of Protein Phosphorylation Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Catabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Signal Transduction Cell Death Regulation Of Cell Cycle Phase Transition Death
Tagcloud ?		anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast	adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von
Tagcloud (Difference) ?		anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast	adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von
Tagcloud (Intersection) ?