PML and SP1

Number of citations of the paper that reports this interaction (PubMedID 9819401)
61

Data Source:
HPRD (in vitro, in vivo)

		PML	SP1
Description		PML nuclear body scaffold	Sp1 transcription factor
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Matrix PML Body Early Endosome Membrane Nuclear Membrane	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Binding Identical Protein Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Molecular Adaptor Activity Ubiquitin-like Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Defense Response To Virus By Host Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Targeting Protein Import Into Nucleus Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Angiogenesis Protein Sumoylation Myeloid Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator PML Body Organization Protein-containing Complex Localization Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Circadian Regulation Of Gene Expression Negative Regulation Of Translation In Response To Oxidative Stress Response To Cytokine Protein Localization To Nucleus Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Cell Fate Commitment Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Retinoic Acid Receptor Signaling Pathway Rhythmic Process Protein Stabilization Regulation Of Protein Metabolic Process Maintenance Of Protein Location In Nucleus Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Cellular Localization SMAD Protein Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Protein-containing Complex Assembly Regulation Of Biological Quality Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Senescence Oncogene-induced Cell Senescence Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Localization To Chromosome, Telomeric Region Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Cellular Response To Insulin Stimulus Response To Hydroperoxide Cellular Response To Zinc Ion Starvation Positive Regulation Of Blood Vessel Endothelial Cell Migration Host-mediated Activation Of Viral Transcription Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estrogen Stimulus Positive Regulation Of Amyloid-beta Formation Cellular Response To Wortmannin Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression SARS-CoV-1 targets host intracellular signalling and regulatory pathways Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Positive Regulation of CDH1 Gene Transcription NFE2L2 regulating tumorigenic genes TGFBR3 expression
Drugs		Arsenic trioxide
Diseases		Acute myeloid leukemia (AML)
GWAS		Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) ( 29899525) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Height ( 20881960 25282103 28552196) Hip circumference adjusted for BMI ( 34021172) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Myopia (pathological) ( 23049088) Paget's disease ( 21623375) Physical activity (overall physical activity time) ( 30531941) White blood cell count ( 32888494)	Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		111 interacting genes: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHEK2 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 ERCC6 FOS FXR1 GATA1 GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A KLHL20 MAD1L1 MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NACC1 NCOA2 NCOR1 NCOR2 NFKB1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PSMA3 RARA RB1 RBX1 RELA RNF125 RPL11 RXRA SENP1 SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SMAD3 SNCA SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIB3 TRIM24 TRIM27 TRIM69 UBC UBE2I UBE2U UBE3A USP11 USP2 ZBTB16 ZFYVE9 ZNF451	149 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KAT2B KIF1A KLF10 KLF4 KLF6 LDB1 LINC00955 LMO2 MAP1LC3A MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RMP64 RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB5 ZBTB7A
Entrez ID		5371	6667
HPRD ID		00023	01796
Ensembl ID		ENSG00000140464	ENSG00000185591
Uniprot IDs		P29590	P08047
PDB IDs		1BOR 2MVW 2MWX 4WJN 4WJO 5YUF 6IMQ 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 8DJH 8DJI 8J25 8J2P 8YTC	1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus PML Body Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Binding DNA-templated Transcription Apoptotic Process Transcription By RNA Polymerase II Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Cell Communication Programmed Cell Death Cell Death Regulation Of Cell Cycle Transcription Regulator Complex Intracellular Signal Transduction Chromatin Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Sequence-specific Double-stranded DNA Binding Regulation Of MiRNA Metabolic Process DNA-templated Transcription Regulation Of MiRNA Transcription Regulation Of Developmental Process Chromatin Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding
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