PML and ANKRD2

Number of citations of the paper that reports this interaction (PMID 15136035)
34

Data Source:
HPRD (in vitro, in vivo)

		PML	ANKRD2
Gene Name		promyelocytic leukemia	ankyrin repeat domain 2 (stretch responsive muscle)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Early Endosome Membrane Nuclear Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane	Euchromatin Nucleus Cytosol PML Body Sarcomere I Band Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding Protein Homodimerization Activity SMAD Binding Protein Heterodimerization Activity Cobalt Ion Binding	Structural Constituent Of Muscle Titin Binding Protein Kinase B Binding RNA Polymerase II Sequence-specific DNA Binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Targeting Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Negative Regulation Of Cell Growth PML Body Organization Positive Regulation Of Histone Deacetylation Negative Regulation Of Telomere Maintenance Via Telomerase Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Gene Expression Negative Regulation Of Translation In Response To Oxidative Stress Response To Cytokine Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Cell Fate Commitment Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Retinoic Acid Receptor Signaling Pathway Protein Stabilization Maintenance Of Protein Location In Nucleus Defense Response To Virus Negative Regulation Of Telomerase Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Interferon-gamma-mediated Signaling Pathway Branching Involved In Mammary Gland Duct Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Cellular Senescence Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Muscle Organ Development Skeletal Muscle Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Myoblast Differentiation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Height ( 20881960) Myopia (pathological) ( 23049088) Paget's disease ( 21623375)
Protein-Protein Interactions		101 interactors: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 FOS GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NCOA2 NCOR1 NCOR2 NFKB1 NR3C1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PPARG PSMA3 RARA RB1 RBX1 RELA RNF111 RNF125 RNF4 RPL11 RXRA SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SMAD3 SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIM24 TRIM27 TRIM69 UBE2I UBE2U UBE3A ZBTB16 ZFYVE9	8 interactors: FAIM3 HBP1 PML TCAP TP53 TTN YBX1 ZBTB3
Entrez ID		5371	26287
HPRD ID		00023	12460
Ensembl ID		ENSG00000140464	ENSG00000165887
Uniprot IDs		P29590	Q9GZV1
PDB IDs		1BOR
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Gene Expression Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Cell Cycle	Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Detection Of Muscle Stretch Myosin Filament Assembly Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Cardiac Muscle Fiber Development Response To Muscle Stretch Cell Cycle Arrest Adult Heart Development Protein Import Positive Regulation Of Histone Deacetylation Cardiac Myofibril Assembly Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Protein Deacetylation Cardiac Muscle Hypertrophy Photoperiodism Entrainment Of Circadian Clock Muscle Hypertrophy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Senescence Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Histone Deacetylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Actin-mediated Cell Contraction Negative Regulation Of DNA Replication Detection Of Mechanical Stimulus Regulation Of Protein Deacetylation Muscle Fiber Development Response To Gamma Radiation Cardiac Muscle Contraction Sarcomere Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cardiac Muscle Tissue Morphogenesis Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Actin Filament-based Movement Muscle Tissue Morphogenesis Regulation Of Tissue Remodeling Heart Contraction Protein Complex Assembly Cell Cycle Process Cardiac Muscle Cell Development Muscle Organ Morphogenesis Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast	a165v a171t actinin2 alternatively cardiomyopathy compaction competition cypher cytoskeletal differs dilated homologue indication lethality lim mechanosensing motif multiprotein myofibrillar myopathy nomenclature pdz sarcomeres spliced striated sumoylation zasp zaspopathy zm
Tagcloud (Difference) ?		anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast	a165v a171t actinin2 alternatively cardiomyopathy compaction competition cypher cytoskeletal differs dilated homologue indication lethality lim mechanosensing motif multiprotein myofibrillar myopathy nomenclature pdz sarcomeres spliced striated sumoylation zasp zaspopathy zm
Tagcloud (Intersection) ?