CDK12 and EWSR1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDK12	EWSR1
Gene Name		cyclin-dependent kinase 12	EWS RNA-binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin K-CDK12 Complex Nucleus Nucleoplasm Nucleolus Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin Binding	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Processing RNA Splicing Regulation Of MAP Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		7 interactors: EWSR1 MBP PIN1 POLR2A PRPF40A SRSF1 SRSF2	159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		51755	2130
HPRD ID		10849	00592
Ensembl ID		ENSG00000167258	ENSG00000182944
Uniprot IDs		Q9NYV4	Q01844
PDB IDs			2CPE
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Termination Of RNA Polymerase II Transcription Regulation Of Cytokinesis MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Regulation Of RNA Splicing RNA 3'-end Processing Nuclear Export MRNA Transport Transcription, RNA-templated RNA Transport RNA Metabolic Process RNA Localization Defense Response To Nematode Gene Expression MRNA 5'-splice Site Recognition Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Response To Nematode Regulation Of Cell Division Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Interleukin-10 Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Cis Splicing, Via Spliceosome Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Interleukin-4 Production Response To Mercury Ion Regulation Of Cell Morphogenesis Regulation Of Cellular Process Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process 7-methylguanosine MRNA Capping Regulation Of Interleukin-4 Production PiRNA Metabolic Process Regulation Of Cytokine Production Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Substantia Nigra Development	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death
Tagcloud ?		affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Difference) ?		affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Intersection) ?