CDK12 and SRSF1

Number of citations of the paper that reports this interaction (PMID 11683387)
22

Data Source:
HPRD (in vitro)

		CDK12	SRSF1
Gene Name		cyclin-dependent kinase 12	serine/arginine-rich splicing factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin K-CDK12 Complex Nucleus Nucleoplasm Nucleolus Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin Binding	Nucleotide Binding RNA Binding MRNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding
	Biological Process	MRNA Processing RNA Splicing Regulation Of MAP Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain	MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Gene Expression MRNA 3'-end Processing Regulation Of MRNA Stability Regulation Of MRNA Splicing, Via Spliceosome Cardiac Muscle Contraction
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: EWSR1 MBP PIN1 POLR2A PRPF40A SRSF1 SRSF2	41 interactors: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF2 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		51755	6426
HPRD ID		10849	02887
Ensembl ID		ENSG00000167258
Uniprot IDs		Q9NYV4	Q07955 Q59FA2
PDB IDs			1X4A 2M7S 2M8D 2O3D 3BEG
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Termination Of RNA Polymerase II Transcription Regulation Of Cytokinesis MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Regulation Of RNA Splicing RNA 3'-end Processing Nuclear Export MRNA Transport Transcription, RNA-templated RNA Transport RNA Metabolic Process RNA Localization Defense Response To Nematode Gene Expression MRNA 5'-splice Site Recognition Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Response To Nematode Regulation Of Cell Division Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Interleukin-10 Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Cis Splicing, Via Spliceosome Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Interleukin-4 Production Response To Mercury Ion Regulation Of Cell Morphogenesis Regulation Of Cellular Process Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process 7-methylguanosine MRNA Capping Regulation Of Interleukin-4 Production PiRNA Metabolic Process Regulation Of Cytokine Production Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Substantia Nigra Development	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Export From Nucleus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Ribonucleoprotein Complex Assembly MRNA Transport Nuclear Export Termination Of RNA Polymerase II Transcription Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing RNA Transport RNA Localization RNA 3'-end Processing DNA-templated Transcription, Termination Negative Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Biogenesis Negative Regulation Of RNA Splicing Cellular Metabolic Process MRNA Splice Site Selection Transcription From RNA Polymerase II Promoter Cytoplasmic Transport Cellular Macromolecular Complex Assembly Metabolic Process Cellular Component Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Establishment Of Localization In Cell RNA Biosynthetic Process Intracellular Transport Regulation Of Nitrogen Compound Metabolic Process Cellular Localization Positive Regulation Of Gene Expression Peptidyl-threonine Phosphorylation
Tagcloud ?		affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized
Tagcloud (Difference) ?		affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate processing repeat reveals rna sec seq snorna super tagged tefb	altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized
Tagcloud (Intersection) ?		preferentially