SSTR5 and CNR1

Number of citations of the paper that reports this interaction (PubMedID 27984180)
0

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		SSTR5	CNR1
Description		somatostatin receptor 5	cannabinoid receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Actin Cytoskeleton Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Membrane Raft Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cytokinesis Somatostatin Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Axonal Fasciculation Cannabinoid Signaling Pathway Glucose Homeostasis Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Vapreotide Pasireotide Lanreotide Somatostatin Lutetium Lu 177 dotatate Edotreotide gallium Ga-68	Dronabinol Nabilone Ricinoleic acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Logical memory (immediate recall) in normal cognition ( 29274321) Polycystic ovary syndrome ( 25574032)	Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)
Interacting Genes		9 interacting genes: ADCY10 CNR1 CORT DRD2 GOPC PDZK1 PEX5 SST SSTR1	10 interacting genes: ADORA2A BECN2 GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5
Entrez ID		6755	1268
HPRD ID		01677	00259
Ensembl ID		ENSG00000162009	ENSG00000118432
Uniprot IDs		P35346	P21554 S5TLS4 V5KA96
PDB IDs		8X8L 8X8N 8ZBE 8ZCJ	1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B 7FEE 7V3Z 7WV9 8GAG 8GHV 8IKG 8IKH 8K8J 8WRZ 8WU1 9B54 9B65 9B9Y 9B9Z 9BA0 9ERX
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Somatostatin Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling GABA-ergic Synapse Regulation Of Monoatomic Anion Transport Positive Regulation Of Developmental Growth Positive Regulation Of Multicellular Organism Growth Signaling Cell-cell Signaling Telencephalon Cell Migration Positive Regulation Of Growth Forebrain Cell Migration Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Developmental Growth Regulation Of Multicellular Organism Growth Bicarbonate Binding Negative Regulation Of Anion Channel Activity Cannabinoid Receptor Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Forebrain Development Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Cardiac Muscle Cell Contraction Neuron Projection Retraction Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Protein Propionyltransferase Activity Axon Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Synapse Regulation Of Monoatomic Ion Transport Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Regulation Of Protein Localization Negative Regulation Of Dopamine Receptor Signaling Pathway Peroxisome Targeting Sequence Binding Central Region Of Growth Cone Hormone Activity Neuromuscular Process Response To Estradiol Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dendrite	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Urine Volume Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Neuropeptide Signaling Pathway GTP Binding Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Midbody Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Secretion By Cell Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Postsynaptic Signal Transduction Regulation Of Protein Secretion Signal Transduction Regulation Of ERK1 And ERK2 Cascade Excitatory Postsynaptic Potential Hepatocyte Growth Factor Receptor Activity Plasma Membrane Ciliary Basal Body Regulation Of Cell Communication Regulation Of Signaling GDP Binding Feeding Behavior G Protein-coupled Receptor Activity Orexin Receptor Activity G Protein-coupled Receptor Catabolic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Protein Transport Positive Regulation Of Acetylcholine Secretion, Neurotransmission Nucleotide Binding D2 Dopamine Receptor Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Cell Division Positive Regulation Of MAPK Cascade Regulation Of Acetylcholine Secretion, Neurotransmission Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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